Molecular identification of Mycobacterium chimaera as a cause of infection in a patient with chronic obstructive pulmonary disease

Abstract This report describes a case of Mycobacterium chimaera infection in a patient with a history of chronic obstructive pulmonary disease where the organism was identified by using molecular methods. M. chimaera was identified from fresh lung tissue and from an instrument-negative mycobacterial...

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Bibliographic Details
Published in:Diagnostic microbiology and infectious disease 2009-03, Vol.63 (3), p.292-295
Main Authors: Bills, Nathan D, Hinrichs, Steven H, Aden, Tricia A, Wickert, Robert S, Iwen, Peter C
Format: Article
Language:English
Subjects:
Aged
Bacteriology
Biological and medical sciences
Chronic obstructive pulmonary disease
DNA, Bacterial - chemistry
DNA, Bacterial - genetics
DNA, Ribosomal Spacer - chemistry
DNA, Ribosomal Spacer - genetics
Equipment and Supplies - microbiology
Female
Fundamental and applied biological sciences. Psychology
Humans
Infectious Disease
Infectious diseases
Internal Medicine
Lung - metabolism
Medical sciences
Microbiology
Miscellaneous
Molecular identification
Molecular Sequence Data
Mycobacterium
Mycobacterium - classification
Mycobacterium - genetics
Mycobacterium - isolation & purification
Mycobacterium chimaera
Mycobacterium Infections - diagnosis
Mycobacterium Infections - microbiology
Pulmonary Disease, Chronic Obstructive - microbiology
Sequence Analysis, DNA
Sequence Homology, Nucleic Acid
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Summary:Abstract This report describes a case of Mycobacterium chimaera infection in a patient with a history of chronic obstructive pulmonary disease where the organism was identified by using molecular methods. M. chimaera was identified from fresh lung tissue and from an instrument-negative mycobacterial growth indicator tube broth culture. The utility of using sequence analysis of the internal transcribed spacer region for the rapid identification of a slow-growing nontuberculous Mycobacterium spp. where conventional culture methods were not successful was shown.
ISSN:0732-8893
1879-0070
DOI:10.1016/j.diagmicrobio.2008.12.002