Preoperative evaluation of prognosis in breast cancer patients by [18F]2-deoxy-2-fluoro-D-glucose-positron emission tomography

[18F]2-Deoxy-2-fluoro-D-glucose (FDG)-positron emission tomography (PET) was applied to breast cancer patients for the purpose of preoperative evaluation of patient prognosis with more accuracy than conventional TNM staging. FDG-PET was performed preoperatively in 81 patients with breast cancer, and...

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Bibliographic Details
Published in:Journal of cancer research and clinical oncology 2004-05, Vol.130 (5), p.273-278
Main Authors: INOUE, Tomoo, YUTANI, Kenji, TAGUCHI, Tetsuya, TAMAKI, Yasuhiro, SHIBA, Eiichi, NOGUCHI, Shinzaburo
Format: Article
Language:English
Subjects:
Adult
Aged
Antineoplastic agents
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Axilla
Biological and medical sciences
Breast cancer
Breast Neoplasms - diagnostic imaging
Breast Neoplasms - drug therapy
Breast Neoplasms - secondary
Diagnostic tests
Female
Fluorodeoxyglucose F18 - pharmacokinetics
Humans
Lymph Node Excision
Lymph Nodes - diagnostic imaging
Lymph Nodes - pathology
Lymph Nodes - surgery
Medical sciences
Middle Aged
Neoadjuvant Therapy
Neoplasm Recurrence, Local - diagnostic imaging
Neoplasm Recurrence, Local - drug therapy
Neoplasm Recurrence, Local - pathology
Neoplasm Staging
Oncology
Pharmacology. Drug treatments
Predictive Value of Tests
Preoperative Care
Prognosis
Radiopharmaceuticals - pharmacokinetics
Tomography
Tomography, Emission-Computed
Tumors
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Description
Summary:[18F]2-Deoxy-2-fluoro-D-glucose (FDG)-positron emission tomography (PET) was applied to breast cancer patients for the purpose of preoperative evaluation of patient prognosis with more accuracy than conventional TNM staging. FDG-PET was performed preoperatively in 81 patients with breast cancer, and the maximum standardized uptake value (SUVmax) of tumors as well as the focal accumulation of FDG in the axillary region (PET-N status) were investigated in their association with patient prognosis. The SUVmax high group (n=40) showed a significantly (P=0.011) poorer prognosis than the SUVmax low group (n=41) (5-year disease-free survival (DFS) rates; 75.0% vs 95.1%). FDG-PET was more accurate in the diagnosis of axillary lymph node status than physical examination, i.e., diagnostic accuracy was 80% and 70% for FDG-PET and physical examination, respectively. The combination of high SUVmax and positive PET-N (+) was shown to be a highly significant risk factor being independent of the clinical T and N factors, i.e., patients with high SUVmax and positive PET-N (+) showed a significantly (P
ISSN:0171-5216
1432-1335
DOI:10.1007/s00432-003-0536-5