B-6 vitamers and 4-pyridoxic acid in the plasma, erythrocytes, and urine of postmenopausal women

Background: Although many studies have reported reduced vitamin B-6 status with aging, little information is available about the specific effects of menopause. Objective: We aimed to examine vitamin B-6 metabolism in premenopausal and early postmenopausal women. Design: We examined dietary intake an...

Full description

Saved in:
Bibliographic Details
Published in:The American journal of clinical nutrition 2004-10, Vol.80 (4), p.946-951
Main Authors: Masse, P.G, Mahuren, J.D, Tranchant, C, Dosy, J
Format: Article
Language:English
Subjects:
4-pyridoxic acid
Adult
Aging - metabolism
Biological and medical sciences
blood plasma
Erythrocytes
Erythrocytes - chemistry
Estradiol - blood
Feeding. Feeding behavior
Female
food intake
Fundamental and applied biological sciences. Psychology
Humans
Menopause
Metabolism
metabolites
Middle Aged
nutrient uptake
Nutritional Status
Plasma
postmenopausal women
Postmenopause - blood
Postmenopause - metabolism
Postmenopause - urine
Pyridoxal Phosphate - blood
Pyridoxal Phosphate - metabolism
Pyridoxic Acid - blood
Pyridoxic Acid - urine
pyridoxine
Pyridoxine - blood
Pyridoxine - metabolism
senescence
Urine
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vitamin B
Vitamin B 6 - administration & dosage
Vitamin B 6 - blood
Vitamin B 6 - urine
vitamin metabolism
Women
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: Although many studies have reported reduced vitamin B-6 status with aging, little information is available about the specific effects of menopause. Objective: We aimed to examine vitamin B-6 metabolism in premenopausal and early postmenopausal women. Design: We examined dietary intake and vitamin B-6 metabolites in the plasma, erythrocytes, and urine of 30 premenopausal women (+/- SD age: 41.9 +/- 4.8 y) and 30 women (aged 54.0 +/- 3.8 y) who were 4.0 +/- 1.4 y past menopause. Results: Vitamin B-6 intake in the postmenopausal group (1.97+/- 0.40 mg/d) was significantly greater than that in the premenopausal group (1.63 +/- 0.50 mg/d). Plasma pyridoxal phosphate (PLP) and pyridoxal concentrations and erythrocyte PLP, pyridoxal, and pyridoxamine phosphate concentrations were in the normal range in both groups and did not differ significantly between the 2 groups. Plasma and erythrocyte 4-pyridoxic acid (4-PA) concentrations were significantly higher in the postmenopausal group than in the premenopausal group, which may have been due at least partly to the slightly higher vitamin B-6 intake of the former group. Erythrocyte 4-PA was correlated (r = -0.37, P < 0.01) with serum estradiol in both groups. Urinary 4-PA did not differ significantly between the 2 groups. The serum phosphate concentration was higher in the postmenopausal group than in the premenopausal group, and it was correlated (r = 0.40, P < 0.01) with plasma PLP. Inhibition of alkaline phosphatase by the increased phosphate may help to increase plasma PLP.
ISSN:0002-9165
1938-3207
DOI:10.1093/ajcn/80.4.946