Significant effects of diacylglycerol on body fat and lipid metabolism in patients on hemodialysis

Aims: The long-term effects of dietary diacylglycerol (DAG) on body fat and lipid metabolism were studied in patients undergoing hemodialysis (HD). Methods: Ten patients (seven males, three females) ranging in age from 40 to 64 years were enrolled. During the test period, 9.8 g of DAG was ingested p...

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Bibliographic Details
Published in:Clinical nutrition (Edinburgh, Scotland) Scotland), 2004-10, Vol.23 (5), p.1122-1126
Main Authors: Teramoto, T., Watanabe, H., Ito, K., Omata, Y., Furukawa, T., Shimoda, K., Hoshino, M., Nagao, T., Naito, S.
Format: Article
Language:English
Subjects:
Abdomen - anatomy & histology
Abdominal fat
Adipose Tissue - drug effects
Adipose Tissue - metabolism
Adult
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Body Composition - drug effects
Body Composition - physiology
Diacylglycerol
Dietary fat
Diglycerides - administration & dosage
Electrophoresis, Agar Gel
Emergency and intensive care: renal failure. Dialysis management
Female
Hemodialysis
Humans
Intensive care medicine
Lipoproteins, HDL - blood
Lipoproteins, HDL - metabolism
Lipoproteins, VLDL - blood
Lipoproteins, VLDL - metabolism
Male
Medical sciences
Middle Aged
Renal Dialysis
Serum lipid
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Summary:Aims: The long-term effects of dietary diacylglycerol (DAG) on body fat and lipid metabolism were studied in patients undergoing hemodialysis (HD). Methods: Ten patients (seven males, three females) ranging in age from 40 to 64 years were enrolled. During the test period, 9.8 g of DAG was ingested per day for 3 months. Results: Body mass index did not change throughout the study. The abdominal fat area measured by CT scan decreased significantly at 3 months, and increased significantly 3 months after completion of the DAG ingestion period. The serum composition of very low-density lipoprotein (VLDL) decreased significantly at 3 months and high-density lipoprotein (HDL) increased significantly at 3 months; these were determined using polyacrylamide gel electrophoresis. Serum lipoprotein (a) decreased significantly at 3 months. Conclusions: Our study showed that 3-month ingestion of DAG reduced the amount of abdominal fat and improved serum lipid profiles in free-living HD patients.
ISSN:0261-5614
1532-1983
DOI:10.1016/j.clnu.2004.02.005