Comparison of endometrial and subendometrial blood flow measured by three-dimensional power Doppler ultrasound between stimulated and natural cycles in the same patients

BACKGROUND: Low implantation rates in stimulated IVF cycles may be related to suboptimal endometrial perfusion. Endometrial and subendometrial blood flow was compared between stimulated and natural cycles in the same patients undergoing IVF. METHODS: Three-dimensional (3D) ultrasound examination wit...

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Bibliographic Details
Published in:Human reproduction (Oxford) 2004-10, Vol.19 (10), p.2385-2390
Main Authors: Ng, Ernest Hung Yu, Chan, Carina Chi Wai, Tang, Oi Shan, Yeung, William Shu Biu, Ho, Pak Chung
Format: Article
Language:English
Subjects:
Adult
Arteries - diagnostic imaging
Biological and medical sciences
Blood Vessels - diagnostic imaging
endometrial and subendometrial blood flow
Endometrium - blood supply
Endometrium - diagnostic imaging
Female
Fundamental and applied biological sciences. Psychology
Humans
Imaging, Three-Dimensional
Infertility, Female - diagnostic imaging
Infertility, Female - physiopathology
Mammalian female genital system
Morphology. Physiology
natural cycles
Ovulation Induction
Pulse
Regional Blood Flow
stimulation
three-dimensional power Doppler
Ultrasonography, Doppler
Uterus - blood supply
Vascular Resistance
Vertebrates: reproduction
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Summary:BACKGROUND: Low implantation rates in stimulated IVF cycles may be related to suboptimal endometrial perfusion. Endometrial and subendometrial blood flow was compared between stimulated and natural cycles in the same patients undergoing IVF. METHODS: Three-dimensional (3D) ultrasound examination with power Doppler was performed in stimulated and natural cycles of 67 consecutive patients to measure endometrial thickness, uterine artery pulsatility index/resistance index, endometrial volume, vascularization index (VI)/flow index (FI)/vascularization flow index (VFI) of endometrial and subendometrial regions. RESULTS: Endometrial and subendometrial blood flow was absent in four (6.0%) patients in the stimulated cycle and two (3.0%) patients in the natural cycle. Endometrial and subendometrial VI/FI/VFI were significantly lower in stimulated cycles than those in natural cycles. The median (95% CI) decreases in endometrial VI/FI/VFI were 35.8% (−2.5, 216.8), 5.0% (0.1, 12.3) and 48.4% (2.5, 315.3) respectively whereas the corresponding decreases in the subendometrial region were 66.6% (−0.2, 220.5), 4.3% (0.8, 16.2) and 76.3% (41.0, 303.4) respectively. CONCLUSION: Endometrial and subendometrial blood flow was significantly lower in the stimulated cycle than that in the natural cycle.
ISSN:0268-1161
1460-2350
DOI:10.1093/humrep/deh384