Prevalence of factor XIII Val34Leu polymorphism in patients affected by spontaneous subconjunctival hemorrhage

To verify the prevalence of Val34Leu polymorphism in factor XIII A-chain gene (FXIII Val34Leu) in patients with spontaneous subconjunctival hemorrhage (SCH). Nonrandomized case-control study. One hundred seven white patients suffering from one or more episodes of idiopathic SCH and 107 healthy subje...

Full description

Saved in:
Bibliographic Details
Published in:American journal of ophthalmology 2004-09, Vol.138 (3), p.481-484
Main Authors: Parmeggiani, Francesco, Costagliola, Ciro, Incorvaia, Carlo, Gemmati, Donato, D'Angelo, Sergio, Tognazzo, Silvia, Scapoli, Gian Luigi, Sebastiani, Adolfo
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Aged
Aged, 80 and over
Associated diseases and complications
Biological and medical sciences
Case-Control Studies
Conjunctival Diseases - genetics
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Eye Hemorrhage - genetics
Factor XIII - genetics
Female
Genotype & phenotype
Health risk assessment
Hemorrhage
Humans
Leucine
Male
Medical sciences
Middle Aged
Point Mutation
Polymerase Chain Reaction
Polymorphism, Genetic
Population
Prevalence
Valine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To verify the prevalence of Val34Leu polymorphism in factor XIII A-chain gene (FXIII Val34Leu) in patients with spontaneous subconjunctival hemorrhage (SCH). Nonrandomized case-control study. One hundred seven white patients suffering from one or more episodes of idiopathic SCH and 107 healthy subjects were matched for age and gender, and genotyped for FXIII Val34Leu. Anamnestic, ophthalmologic, cardiovascular, and serologic examinations were performed. Frequency of FXIII mutated allele (Leu34) was significantly higher in SCH patients than in controls. Computing together heterozygotes (Val/Leu) and homozygotes (Leu/Leu), genotype distribution was statistically different. In a conditional logistic regression model, the comparison of the three separated genotypes, performed among 25 patients with recurrent idiopathic SCHs and controls, gave significant differences for both Val/Leu and Leu/Leu variables. Both homozygosity and heterozygosity for FXIII Val34Leu predispose to idiopathic SCH, emphasizing the role of Leu34 allele as inherited risk factor for spontaneous, especially recurrent, SCHs.
ISSN:0002-9394
1879-1891
DOI:10.1016/j.ajo.2004.03.017