Reduced expression of connexin 31.1 in larynx cancer is not caused by GJB5 mutations

Lack of regular cell–cell interaction is one major cause for neoplastic growth and metastasis. In head and neck squamous cell carcinomas a 10-fold down-regulation of connexin31.1 ( GJB5) as well as mutations in the TGF-β-receptor-II were reported. We performed mutation screenings in GJB5 and the TGF...

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Bibliographic Details
Published in:Cancer letters 2004-10, Vol.214 (2), p.225-229
Main Authors: Broghammer, Martina, Leistenschneider, Peter, Baus-Loncar, Mirela, Blin, Nikolaus, Sasiadek, Maria M., Pusch, Carsten M.
Format: Article
Language:English
Subjects:
Adult
Aged
Carcinoma, Squamous Cell - genetics
Carcinoma, Squamous Cell - pathology
Case-Control Studies
Cell Communication
Cell–cell interaction
Connexins - biosynthesis
DNA methylation
DNA Mutational Analysis
DNA-Directed DNA Polymerase - pharmacology
Down-Regulation
Female
Genes
Humans
Laryngeal Neoplasms - genetics
Laryngeal Neoplasms - pathology
Larynx cancer
Loss of Heterozygosity
Male
Middle Aged
Mutation
Polymerase Chain Reaction
Protein-Serine-Threonine Kinases
Receptors, Transforming Growth Factor beta - genetics
Studies
Transforming growth factor receptor
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Summary:Lack of regular cell–cell interaction is one major cause for neoplastic growth and metastasis. In head and neck squamous cell carcinomas a 10-fold down-regulation of connexin31.1 ( GJB5) as well as mutations in the TGF-β-receptor-II were reported. We performed mutation screenings in GJB5 and the TGF-β-receptor-II poly(10)adenine hot spot employing larynx cancer samples of 10 patients. Variable length of the TGF-β-receptor-II adenine homopolymer in controls and tumours indicate a high slippage error rate of the DNA polymerases rendering mutational analyses inconsistent. Lack of GJB5 mutations in the entire tumour collection suggests that this gene is not primarily involved in laryngeal tumorigenesis.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2004.04.004