Maternal Cigarette Smoking, Metabolic Enzyme Polymorphism, and Developmental Events in the Early Stages of Extrauterine Life

The recent observation that maternal ACPI genotype has an interactive effect with smoking on intrauterine development prompted us to search for a possible interaction effect between smoking and ACPI genotype on haptoglobin (Hp) development in the neonatal period. ACPI is a highly polymorphic protein...

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Bibliographic Details
Published in:Human biology 2004-04, Vol.76 (2), p.289-297
Main Authors: BOTTINI, N., GLORIA-BOTTINI, F., MAGRINI, A., STEFANINI, L., COSMI, E., BERGAMASCHI, A., COSMI, E.V., BOTTINI, E.
Format: Article
Language:English
Subjects:
Biological anthropology
Child development
Cigarette smoking
Developmental biology
Enzyme polymorphism
Enzymes
Female
Fetal growth retardation
Fetus
Genetic polymorphisms
Genetic variation
Genotype
Genotype & phenotype
Genotypes
Growth retardation
Haptoglobins - analysis
Human biology
Humans
Infant, Newborn
Infants
Mothers
Phosphatases
Polymorphism
Polymorphism, Genetic
Pregnancy
Prenatal Exposure Delayed Effects
Protein isoforms
Protein Tyrosine Phosphatases - genetics
Reproductive system
Risk factors
Signal transduction
Smoking
Tobacco smoking
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Summary:The recent observation that maternal ACPI genotype has an interactive effect with smoking on intrauterine development prompted us to search for a possible interaction effect between smoking and ACPI genotype on haptoglobin (Hp) development in the neonatal period. ACPI is a highly polymorphic protein tyrosine phosphatase involved in signal transduction of several growth factor receptors. The enzyme is composed of two isoforms, F and S. We studied 299 infants born in the Department of Obstetrics of the University Hospital of Rome La Sapienza. We found that an interaction between ACPI genotype and smoking has an effect on haptoglobin development: A significant delay of haptoglobin development in infants born to smoking mothers is observed only in infants with the ACPI *B/*B genotype, which shows the highest concentration of the ACPI F isoform. The results indicate that the ACPI genotype modifies the deleterious effects of smoking on development not only during intrauterine life but also during the early stage of extrauterine life.
ISSN:0018-7143
1534-6617
1534-6617
DOI:10.1353/hub.2004.0029