Low frequency of human papillomavirus DNA in breast cancer tissue

Human papillomavirus (HPV) is considered the aetiological agent for cervical cancer. Several reports have addressed a relationship with HPV and breast cancer, as different HPVs have been identified. The purpose of this study was to detect HPV DNA in 67 breast cancer patients and 40 non-malignant dis...

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Bibliographic Details
Published in:Breast cancer research and treatment 2009-03, Vol.114 (1), p.189-194
Main Authors: Mendizabal-Ruiz, A. P, Morales, J. A, Ramírez-Jirano, L. J, Padilla-Rosas, M, Morán-Moguel, M. C, Montoya-Fuentes, H
Format: Article
Language:English
Subjects:
Adult
Aged
Alphapapillomavirus - isolation & purification
Biological and medical sciences
Breast - virology
Breast cancer
Breast Neoplasms - virology
Cancer research
Cancer therapies
Deoxyribonucleic acid
DNA
DNA, Viral - isolation & purification
Epidemiology
Female
Gynecology. Andrology. Obstetrics
Human papillomavirus
Humans
Infectious diseases
Mammary gland diseases
Medical sciences
Medicine
Medicine & Public Health
Middle Aged
Oncology
Papillomavirus Infections - virology
Tumors
Viral diseases
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Summary:Human papillomavirus (HPV) is considered the aetiological agent for cervical cancer. Several reports have addressed a relationship with HPV and breast cancer, as different HPVs have been identified. The purpose of this study was to detect HPV DNA in 67 breast cancer patients and 40 non-malignant disease breast tissues by means of Polymerase Chain Reaction with consensus primers. The frequency of HPV in the cases group were 4.4% (3/67) and no positive samples among the reference group were identified. From the 3 positive samples, HPV types 16, 18 and 33 were identified by restriction patterns and direct sequencing. The high diversity among detection in the related studies shows that population genomic heterogeneity plays an important role in the disease. The low frequency detected in the present study suggests that HPV does not play an important role in breast cancer.
ISSN:0167-6806
1573-7217
DOI:10.1007/s10549-008-9989-1