Hypertension and daytime hypotension found on ambulatory blood pressure is associated with fatigue following stroke and TIA

Background: Fatigue affects up to 68% of subjects following stroke. In non-stroke patients, associations are reported between chronic fatigue and both hypertension and hypotension. We hypothesized that, in patients with stroke or transient ischaemic attack (TIA), an association may exist between fat...

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Bibliographic Details
Published in:QJM : An International Journal of Medicine 2009-02, Vol.102 (2), p.109-115
Main Authors: Harbison, J.A., Walsh, S., Kenny, R.A.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Blood Pressure - physiology
Blood Pressure Monitoring, Ambulatory
Depressive Disorder - diagnosis
Fatigue - etiology
Female
General aspects
Humans
Hypertension - etiology
Hypotension - etiology
Ischemic Attack, Transient - complications
Ischemic Attack, Transient - physiopathology
Male
Medical sciences
Middle Aged
Neurology
Risk Factors
Severity of Illness Index
Stroke - complications
Stroke - physiopathology
Vascular diseases and vascular malformations of the nervous system
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Summary:Background: Fatigue affects up to 68% of subjects following stroke. In non-stroke patients, associations are reported between chronic fatigue and both hypertension and hypotension. We hypothesized that, in patients with stroke or transient ischaemic attack (TIA), an association may exist between fatigue and abnormal blood pressure (BP) detected on ambulatory monitoring. Methods: Subjects recruited from a secondary prevention clinic underwent 24-h ambulatory BP monitoring and completed a questionnaire including the Fatigue Severity Scale (FSS). Results: One hundred subjects were included (51% female, mean age 69 years). Mean FSS was 3.6 and 42 has a FSS >4 indicative of significant fatigue. Mean daytime BP for all subjects was 134/74 (SD 16/11 mmHg). There was no significant difference in mean BP between patients with and those without significant fatigue. Patients with stroke suffered worse fatigue than those with TIA (mean FSS 3.8 vs. 3.0, P = 0.03). Twenty-four subjects were hypertensive (mean 24-h BP >145/90 mmHg), 26 had a lowest daytime diastolic BP (DBP)
ISSN:1460-2725
1460-2393
DOI:10.1093/qjmed/hcn146