Parvovirus capsid disorders cholesterol-rich membranes

In this study canine parvovirus, CPV, was found to induce disorder in DPPC:cholesterol membranes in acidic conditions. This acidicity-induced fluidizing effect is suggested to originate from the N-terminus of the viral capsid protein VP1. In accordance with the model membrane studies, a fluidizing e...

Full description

Saved in:
Bibliographic Details
Published in:Biochemical and biophysical research communications 2009-02, Vol.379 (2), p.562-566
Main Authors: Pakkanen, Kirsi, Kirjavainen, Sanna, Mäkelä, Anna R., Rintanen, Nina, Oker-Blom, Christian, Jalonen, Tuula O., Vuento, Matti
Format: Article
Language:English
Subjects:
1,2-Dipalmitoylphosphatidylcholine - chemistry
Canine parvovirus
Capsid - chemistry
Capsid Proteins - chemistry
Cholesterol - chemistry
Cholesterol-rich membrane
Di-4-ANEPPDHQ
Hydrogen-Ion Concentration
Membrane disorder
Membrane Fluidity
Membranes, Artificial
Parvovirus
Parvovirus, Canine - chemistry
Virus capsid
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this study canine parvovirus, CPV, was found to induce disorder in DPPC:cholesterol membranes in acidic conditions. This acidicity-induced fluidizing effect is suggested to originate from the N-terminus of the viral capsid protein VP1. In accordance with the model membrane studies, a fluidizing effect was seen also in the endosomal membranes during CPV infection implying an important functional role of the fluidization in the endocytic entry of the virus.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2008.12.116