Vertebral telangiectatic osteosarcoma in a dog

: Telangiectatic osteosarcoma (TOS) affecting the seventh cervical vertebra (C7) was diagnosed in a 4‐year‐old male dog with signs of locomotor dysfunction. Bone lysis and an extradural‐extramedullary mass were observed in radiographs and occipital myelograms. The diagnosis was confirmed by histopat...

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Bibliographic Details
Published in:Veterinary clinical pathology 2004-01, Vol.33 (3), p.159-162
Main Authors: Brellou, G., Papaioannou, N., Patsikas, M., Polizopoulou, Z., Vlemmas, I.
Format: Article
Language:English
Subjects:
Animals
Cervical vertebra
Cervical Vertebrae
Diagnosis, Differential
dog
Dog Diseases - diagnosis
Dog Diseases - pathology
Dogs
Fatal Outcome
immunohistochemistry
Immunohistochemistry - veterinary
Male
osteosarcoma
Osteosarcoma - diagnosis
Osteosarcoma - pathology
Osteosarcoma - veterinary
Spinal Neoplasms - diagnosis
Spinal Neoplasms - pathology
Spinal Neoplasms - veterinary
telangiectatic
TOS
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Summary:: Telangiectatic osteosarcoma (TOS) affecting the seventh cervical vertebra (C7) was diagnosed in a 4‐year‐old male dog with signs of locomotor dysfunction. Bone lysis and an extradural‐extramedullary mass were observed in radiographs and occipital myelograms. The diagnosis was confirmed by histopathologic and immunohistochemical examination of the mass. The tumor was composed of large blood‐filled cavities lined by anaplastic stromal cells (malignant osteoblasts). Around the cavities were characteristic tumor giant cells (“bizarre cells”). Immunohistochemically the tumor cells were positive for proliferating cell nuclear antigen. The lining cells of the cysts were negative for von Willebrand factor. The histologic findings in this case of TOS involving C7 were similar to those seen in other cases of TOS in dogs and in people. Immunohistochemistry was a useful tool for assessing malignancy and for ruling out other differential diagnoses.
ISSN:0275-6382
1939-165X
DOI:10.1111/j.1939-165X.2004.tb00367.x