Structure of Bryostatin 20:  A Symbiont-Produced Chemical Defense for Larvae of the Host Bryozoan, Bugula neritina

Larvae of the marine bryozoan Bugula neritina are defended against potential predators by high concentrations of bryostatins, which are produced by a bacterial symbiont of the bryozoan. From the larvae of B. neritina, three bryostatins, bryostatin 10 (1), the novel bryostatin 20 (2), and an as yet u...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2004-08, Vol.67 (8), p.1412-1414
Main Authors: LOPANIK, Nicole, GUSTAFSON, Kirk R., LINDQUIST, Niels
Format: Article
Language:English
Subjects:
Animal and plant ecology
Animal, plant and microbial ecology
Animals
Autoecology
Bacteria
Bacteria - chemistry
Biological and medical sciences
Bryostatins
Bryozoa - microbiology
Bugula neritina
Ectoprocta
Feeding Behavior
Fundamental and applied biological sciences. Psychology
Lactones - chemistry
Lactones - isolation & purification
Lactones - pharmacology
Larva - physiology
Macrolides - chemistry
Macrolides - isolation & purification
Macrolides - pharmacology
Marine
Marine Biology
Protozoa. Invertebrata
Symbiosis - physiology
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Summary:Larvae of the marine bryozoan Bugula neritina are defended against potential predators by high concentrations of bryostatins, which are produced by a bacterial symbiont of the bryozoan. From the larvae of B. neritina, three bryostatins, bryostatin 10 (1), the novel bryostatin 20 (2), and an as yet uncharacterized bryostatin, were isolated that were unpalatable to fish. These deterrent bryostatins represent the first example from the marine environment of a microbial symbiont producing an antipredator defense for its host. The structure of bryostatin 20 (2) was determined by spectral comparison with previously described bryostatins.
ISSN:0163-3864
1520-6025
DOI:10.1021/np040007k