Modulation of Hematopoietic Stem Cell Homing and Engraftment by CD26

Hematopoietic stem cell homing and engraftment are crucial to transplantation efficiency, and clinical engraftment is severely compromised when donor-cell numbers are limiting. The peptidase CD26 (DPPIV/dipeptidylpeptidase IV) removes dipeptides from the amino terminus of proteins. We present eviden...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2004-08, Vol.305 (5686), p.1000-1003
Main Authors: Christopherson, Kent W., Hangoc, Giao, Mantel, Charlie R., Broxmeyer, Hal E.
Format: Article
Language:English
Subjects:
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Animals
Biological and medical sciences
Blood
Bone marrow
Bone marrow, stem cells transplantation. Graft versus host reaction
Cell Cycle
Cell Movement
Cell Survival
Chemokine CXCL12
Chemokines, CXC - pharmacology
Chemotaxis - drug effects
Chimerism
Cord blood
Cytokines
Dipeptidyl Peptidase 4 - physiology
Donors
Enzymes
Female
Hematopoietic Stem Cell Transplantation
Hematopoietic stem cells
Hematopoietic Stem Cells - physiology
Heterocyclic Compounds - pharmacology
Homing
Immunity
Inhibition
Leukocytes
Medical sciences
Mice
Mice, Inbred C57BL
Migration
Numbers
Oligopeptides - pharmacology
Physiological aspects
Receptors, CXCR4 - antagonists & inhibitors
Stem cells
Tissue transplantation
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
Transplantation
Transplantation of organs, tissues, etc
Transplants & implants
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Summary:Hematopoietic stem cell homing and engraftment are crucial to transplantation efficiency, and clinical engraftment is severely compromised when donor-cell numbers are limiting. The peptidase CD26 (DPPIV/dipeptidylpeptidase IV) removes dipeptides from the amino terminus of proteins. We present evidence that endogenous CD26 expression on donor cells negatively regulates homing and engraftment. By inhibition or deletion of CD26, it was possible to increase greatly the efficiency of transplantation. These results suggest that hematopoietic stem cell engraftment is not absolute, as previously suggested, and indicate that improvement of bone marrow transplant efficiency may be possible in the clinic.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1097071