USF1 implicated in the aetiology of familial combined hyperlipidaemia and the metabolic syndrome

The upstream stimulatory factor (USF) proteins are ubiquitously expressed and, as such, represent unusual candidates for involvement in disorders of carbohydrate and lipid metabolism. Nonetheless, a recent study has reported an association between specific alleles of USF1 and familial combined hyper...

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Bibliographic Details
Published in:Trends in molecular medicine 2004-08, Vol.10 (8), p.362-365
Main Authors: Shoulders, Carol C., Naoumova, Rossi P.
Format: Article
Language:English
Subjects:
DNA-Binding Proteins - physiology
Female
Humans
Hyperlipidemia, Familial Combined - etiology
Hyperlipidemia, Familial Combined - metabolism
Leucine Zippers
Lipid Metabolism
Male
Metabolic Syndrome - etiology
Metabolic Syndrome - metabolism
Pedigree
Transcription Factors - physiology
Upstream Stimulatory Factors
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Summary:The upstream stimulatory factor (USF) proteins are ubiquitously expressed and, as such, represent unusual candidates for involvement in disorders of carbohydrate and lipid metabolism. Nonetheless, a recent study has reported an association between specific alleles of USF1 and familial combined hyperlipidaemia, a common disorder that substantially increases the risk of premature atherosclerotic cardiovascular disease. USF1 might, therefore, also contribute to the metabolic syndrome. The use of chromatin immunoprecipitation methodologies combined with promoter microarray assays will help to define the transcriptional networks that underlie whole-body glucose and lipid homeostasis.
ISSN:1471-4914
1471-499X
DOI:10.1016/j.molmed.2004.06.011