Fighting Cancer: From the Bench to Bedside Using Second Generation Cationic Liposomal Therapeutics

The use of second generation cationic liposomes to deliver cytotoxic drugs to solid tumors is a rational and promising therapeutic approach, given the natural affinity of cationic carrier molecules for the tumor microvasculature. Cationic liposomal therapeutics are effective in the treatment of canc...

Full description

Saved in:
Bibliographic Details
Published in:Journal of pharmaceutical sciences 2009-02, Vol.98 (2), p.411-429
Main Authors: Campbell, Robert B., Ying, Bo, Kuesters, Geoffrey M., Hemphill, Ryan
Format: Article
Language:English
Subjects:
Angiogenesis Inhibitors - administration & dosage
Angiogenesis Inhibitors - therapeutic use
Animals
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - metabolism
Biological and medical sciences
cancer
cancer chemotherapy
cationic lipids
Cations
Chemistry, Pharmaceutical
Drug Compounding
Drug Design
drug targeting
endothelial
Endothelium, Vascular - drug effects
Endothelium, Vascular - metabolism
General pharmacology
Genetic Therapy - methods
Humans
Lipids - chemistry
Liposomes
Medical sciences
Mice
nanoparticles
nanotechnology
Neoplasms - blood supply
Neoplasms - drug therapy
Neoplasms - genetics
Neoplasms - metabolism
Neoplasms, Experimental - therapy
Neovascularization, Pathologic - genetics
Neovascularization, Pathologic - metabolism
Neovascularization, Pathologic - prevention & control
pegylation
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
targeted drug delivery
Transfection
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The use of second generation cationic liposomes to deliver cytotoxic drugs to solid tumors is a rational and promising therapeutic approach, given the natural affinity of cationic carrier molecules for the tumor microvasculature. Cationic liposomal therapeutics are effective in the treatment of cancers that are resistant to conventional chemotherapy and other treatment modalities. Researchers are now exploring novel ways to combine cationic nanosystems with other treatment approaches. For example, strategies for using cationic liposomes with hyperthermia or magnetic fields have been evaluated. Drug‐loaded cationic liposomes have been documented to induce tumor vascular defects, alter vascular function and limit the growth of the primary tumors and metastasis. In this review, we discuss general features of the endothelium as a function of its tissue environment. We discuss the rationale for targeting tumor vessels over the tumor interstitial matrix, and for the development of second generation cationic lipids and liposomes for tumor vascular targeting. We evaluate the benefits of incorporating the polymer polyethylene‐glycol (PEG) in conventional and cationic liposomes for nonspecific and relatively vascular‐specific tumor targeting, respectively. Finally, we review preclinical and clinical investigations evaluating drug‐loaded cationic liposomes in cancer treatment. © 2008 Wiley‐Liss, Inc. and the American Pharmacists Association J Pharm Sci 98:411–429, 2009
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.21458