C-Reactive protein is inversely related to physical fitness in middle-aged subjects

Introduction: Physical fitness has a protective effect with regard to the risk of developing coronary disease or diabetes. C-reactive protein (CRP) levels are directly related to increased risk of coronary disease and diabetes. However, data on the association between physical fitness and CRP are sp...

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Bibliographic Details
Published in:Atherosclerosis 2004-09, Vol.176 (1), p.173-179
Main Authors: Aronson, Doron, Sheikh-Ahmad, Muhammad, Avizohar, Ophir, Kerner, Arthur, Sella, Ron, Bartha, Peter, Markiewicz, Walter, Levy, Yishai, Brook, Gerald J
Format: Article
Language:English
Subjects:
Adult
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
C-reactive protein
C-Reactive Protein - metabolism
Cardiology. Vascular system
Coronary Artery Disease - epidemiology
Coronary Artery Disease - immunology
Coronary Artery Disease - metabolism
Diabetes Mellitus, Type 2 - epidemiology
Diabetes Mellitus, Type 2 - immunology
Diabetes Mellitus, Type 2 - metabolism
Female
Fitness
Humans
Inflammation
Male
Medical sciences
Middle Aged
Miscellaneous
Neurosurgery
Obesity
Obesity - epidemiology
Obesity - immunology
Obesity - metabolism
Physical fitness
Physical Fitness - physiology
Regression Analysis
Risk Factors
Skull, brain, vascular surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
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Summary:Introduction: Physical fitness has a protective effect with regard to the risk of developing coronary disease or diabetes. C-reactive protein (CRP) levels are directly related to increased risk of coronary disease and diabetes. However, data on the association between physical fitness and CRP are sparse. Methods: Physical fitness was assessed in a population-based cross-sectional study ( n = 892; age 50 ± 9 years) using the Bruce treadmill protocol. CRP was measured using a high-sensitivity assay. Results: Geometric mean CRP levels were calculated across quartiles of physical fitness after adjustment for age, gender, body mass index, smoking habit, presence of diabetes and hypertension, HDL cholesterol and triglyceride levels, and use of hormone replacement therapy, statins, and aspirin. CRP levels decreased with increasing quartiles of fitness ( P for trend 3 mg/L) CRP level (OR 0.53; 95% CI 0.39–0.71, P = 0.007). Conclusion: CRP concentration decreases continuously with increasing levels of physical fitness. The health-related salutary effects of physical fitness may be mediated, in part, through an antiinflammatory mechanism.
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2004.04.025