Sulfated modification of the water-soluble polysaccharides from Polyporus albicans mycelia and its potential biological activities

In this study, three chemically sulfated polysaccharides (SPAPs) were derived from one water-soluble polysaccharide (PAP) of Polyporus albicans mycelia by chlorosulfonic acid-pyridine method. The effects of polysaccharides on the immune function were examined after the mice were intragastrical admin...

Full description

Saved in:
Bibliographic Details
Published in:International journal of biological macromolecules 2009, Vol.44 (1), p.14-17
Main Authors: Sun, Yongxu, Liang, Haitao, Cai, Guangzhi, Guan, Shuwen, Tong, Haibin, Yang, Xiudong, Liu, Jicheng
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - administration & dosage
Adjuvants, Immunologic - chemistry
Animals
Biological activities
Cell Proliferation - drug effects
Dose-Response Relationship, Drug
Lymphocytes - drug effects
Macrophage
Macrophages - drug effects
Mice
Polyporus - chemistry
Polyporus albicans
Polysaccharide
Polysaccharides - administration & dosage
Polysaccharides - chemistry
Pyridines - chemistry
Sulfated modification
Sulfonic Acids - chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this study, three chemically sulfated polysaccharides (SPAPs) were derived from one water-soluble polysaccharide (PAP) of Polyporus albicans mycelia by chlorosulfonic acid-pyridine method. The effects of polysaccharides on the immune function were examined after the mice were intragastrical administrated with polysaccharides at three doses of 100, 200, and 300 mg/kg body weight for 7 days. The results showed that both the lymphocytes proliferation and macrophage function were significantly enhanced by SPAP in all groups along with the increase of the substitution degree and dose ( P < 0.01). It indicated that SPAP could be a potential immunostimulants used in the food and pharmaceutical industry.
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2008.09.010