Comparison of biomechanical and structural properties between human aortic and pulmonary valve

Objective: Pulmonary valve autografts have been reported as clinically effective for replacement of diseased aortic valve (Ross procedure). Published data about pulmonary valve mechanical and structural suitability as a long-term substitute for aortic valve are limited. The aim of this study was to...

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Bibliographic Details
Published in:European journal of cardio-thoracic surgery 2004-09, Vol.26 (3), p.634-639
Main Authors: Stradins, Peteris, Lacis, Romans, Ozolanta, Iveta, Purina, Biruta, Ose, Velta, Feldmane, Laila, Kasyanov, Vladimir
Format: Article
Language:English
Subjects:
Adult
Aortic valve
Aortic Valve - anatomy & histology
Aortic Valve - physiology
Aortic Valve - ultrastructure
Biomechanical properties
Elasticity
Humans
Microscopy, Electron, Scanning
Middle Aged
Pulmonary valve
Pulmonary Valve - anatomy & histology
Pulmonary Valve - physiology
Pulmonary Valve - ultrastructure
Ross procedure
Stress, Mechanical
Structural properties
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Summary:Objective: Pulmonary valve autografts have been reported as clinically effective for replacement of diseased aortic valve (Ross procedure). Published data about pulmonary valve mechanical and structural suitability as a long-term substitute for aortic valve are limited. The aim of this study was to compare aortic and pulmonary valve properties. Methods: Experimental studies of biomechanical properties and structure of aortic and pulmonary valves were carried out on pathologically unchanged human heart valves, collected from 11 cadaveric hearts. Biomechanical properties of 84 specimens (all valve elements: cusps, fibrous ring, commissures, sinotubular junction, sinuses) were investigated using uniaxial tensile tests. Ultrastructure was studied using transmission and scanning electron microscopy. Results: Ultimate stress in circumferential direction for pulmonary valve cusps is higher than for aortic valve (2.78±1.05 and 1.74±0.29 MPa, respectively). Ultimate stress in radial direction for pulmonary and aortic cusps is practically the same (0.29±0.06 and 0.32±0.04 MPa, respectively). In ultrastructural study, different layout and density in each construction element are determined. The aortic and pulmonary valves have common ultrastructural properties. Conclusions: Mechanical differences between aortic and pulmonary valve are minimal. Ultrastructural studies show that the aortic and pulmonary valves have similar structural elements and architecture. This investigation suggests that the pulmonary valve can be considered mechanically and structurally suitable for use as an aortic valve replacement.
ISSN:1010-7940
1873-734X
DOI:10.1016/j.ejcts.2004.05.043