Segmental degeneration in the cervical spine and associated changes in dorsal root ganglia

Degenerative change in cervical segments C5–C7 was documented to determine whether osteo‐ligamentous adaptations were age‐related. In addition, companion morphological studies were carried out to determine whether parallel changes occurred in related soft tissues, including DRG. Independent of the p...

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Bibliographic Details
Published in:Clinical anatomy (New York, N.Y.) N.Y.), 2004, Vol.17 (6), p.468-477
Main Authors: Boyd-Clark, L.C., Briggs, C.A., Galea, M.P.
Format: Article
Language:English
Subjects:
Adaptation, Physiological
Adolescent
Adult
Aged
Aging
Autopsy
Cadaver
Cervical Vertebrae - pathology
Child
Child, Preschool
dorsal root ganglion morphology
Female
Ganglia, Spinal - pathology
Humans
Inflammation
Male
Mast Cells
Middle Aged
Nerve Compression Syndromes - etiology
Neuropeptides - analysis
Neuropeptides - biosynthesis
osteo-ligamentous adaptation
Pain - etiology
Severity of Illness Index
soft tissue changes
Spinal Diseases - complications
Spinal Diseases - physiopathology
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Summary:Degenerative change in cervical segments C5–C7 was documented to determine whether osteo‐ligamentous adaptations were age‐related. In addition, companion morphological studies were carried out to determine whether parallel changes occurred in related soft tissues, including DRG. Independent of the provoking stimulus, aberrant soft tissue change may be expected with segmental degeneration. Two associations were identified: between the incidence of segmental degeneration and severity of DRG distortion, and between segmental degeneration and DRG inflammatory mast cell density. Peripheral type C cells seemed more susceptible to compression in circumstances of DRG distortion. In light of neuropeptide expression in these cell types, predominant type C cell compression may be clinically relevant in the noxious cascade contributing to the sensation of pain. Clin. Anat. 17:468–477, 2004. © 2004 Wiley‐Liss, Inc.
ISSN:0897-3806
1098-2353
DOI:10.1002/ca.10217