Studies on the synthesis and characterization of four trans-planaramineplatinum(II) complexes of the form trans-PtL(NH3)CL2 where L = 2-hydroxypyridine, 3-hydroxypyridine, imidazole, and imidazo(1,2-α)pyridine

Four trans-planaramineplatinum(II) complexes code named YH9, YH10, YH11 and YH12, each of the form trans-PtL(NH3)Cl2 where L = 2-hydroxypyridine and 3-hydroxypyridine, imidazole, and imidazo(1,2-α)pyridine for YH9, YH10, YH11 and YH12, respectively. All of the compounds have significant anticancer a...

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Bibliographic Details
Published in:European journal of medicinal chemistry 2004-08, Vol.39 (8), p.691-697
Main Authors: Huq, Fazlul, Daghriri, Hassan, Yu, Jun Qing, Beale, Philip, Fisher, Keith
Format: Article
Language:English
Subjects:
2-Hydroxypyridine
3-Hydroxypyridine
Anticancer activity
Antineoplastic agents
Biological and medical sciences
Cell Line, Tumor
Cisplatin
General aspects
Humans
Imidazole
Imidazoles - analysis
Imidazoles - chemical synthesis
Magnetic Resonance Spectroscopy
Medical sciences
Organoplatinum Compounds - analysis
Organoplatinum Compounds - chemical synthesis
Pharmacology. Drug treatments
Pyridines - analysis
Pyridines - chemical synthesis
Pyridones - analysis
Pyridones - chemical synthesis
Spectrum Analysis, Raman
Thymine - analogs & derivatives
Thymine - analysis
Thymine - chemical synthesis
Transplatin
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Summary:Four trans-planaramineplatinum(II) complexes code named YH9, YH10, YH11 and YH12, each of the form trans-PtL(NH3)Cl2 where L = 2-hydroxypyridine and 3-hydroxypyridine, imidazole, and imidazo(1,2-α)pyridine for YH9, YH10, YH11 and YH12, respectively. All of the compounds have significant anticancer activity against human cancer cell lines. YH12 is found to be significantly more active than cisplatin against cisplatin-resistant ovary cell line A2780cisR.
ISSN:0223-5234
1768-3254
DOI:10.1016/j.ejmech.2004.04.005