Design and optimization of a new self-nanoemulsifying drug delivery system

To improve the dissolution rate of ibuprofen, a model poorly water soluble drug, self-nanoemulsifying drug delivery systems (SNEDDS) were developed. Various surfactants and oils were screened as candidates for SNEDDS on the basis of droplet size of the resulting emulsions. The influence of the const...

Full description

Saved in:
Bibliographic Details
Published in:Journal of colloid and interface science 2009-02, Vol.330 (2), p.443-448
Main Authors: Wang, Lijuan, Dong, Jinfeng, Chen, Jing, Eastoe, Julian, Li, Xuefeng
Format: Article
Language:English
Subjects:
Chemistry
Colloidal state and disperse state
Dissolution rate
Droplet size
Drug Delivery Systems - methods
Drug Design
Emulsions - chemistry
Emulsions. Microemulsions. Foams
Exact sciences and technology
General and physical chemistry
Ibuprofen
Ibuprofen - administration & dosage
Kinetics
Nanostructures
Oils
Self-nanoemulsifying drug delivery systems (SNEDDS)
Solubility
Surface physical chemistry
Surface-Active Agents
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To improve the dissolution rate of ibuprofen, a model poorly water soluble drug, self-nanoemulsifying drug delivery systems (SNEDDS) were developed. Various surfactants and oils were screened as candidates for SNEDDS on the basis of droplet size of the resulting emulsions. The influence of the constituent structure, concentration and the composition of SNEDDS formulations, and the emulsifier HLB value, on the properties of the resulting emulsions was systematically investigated. Several SNEDDS formulations were employed to study the relationship between the emulsion droplet size and the dissolution rate of ibuprofen. The dissolution rate was accelerated by decreasing the nanoemulsion droplet size, and was significantly faster than that from a conventional tablet. The optimal SNEDDS formulation had a mean nanoemulsion droplet diameters of 58 nm in phosphate buffer, pH 6.8 (simulated intestinal fluid), and released ibuprofen more than 95% within 30 min. Therefore, these novel SNEDDS carriers appear to be useful for controlling the release rate of poorly water soluble drugs. In-vitro release of ibuprofen from a conventional tablet and SNEDDS indicates the release of ibuprofen SNEDDS is related to the nanoemulsion droplet size.
ISSN:0021-9797
1095-7103
DOI:10.1016/j.jcis.2008.10.077