(−)-Epigallocatechin gallate/gelatin layer-by-layer assembled films and microcapsules

A new type of protein/polyphenol microcapsules on the basis of naturally occurring polyphenol (−)-epigallocatechin gallate (EGCG) and gelatin, type A, was obtained using the layer-by-layer (LbL) assembly method. The microcapsules show a more pronounced dependence of permeability on molecular weight...

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Bibliographic Details
Published in:Journal of colloid and interface science 2009-02, Vol.330 (2), p.276-283
Main Authors: Shutava, Tatsiana G., Balkundi, Shantanu S., Lvov, Yuri M.
Format: Article
Language:English
Subjects:
(−)-Epigallocatechin gallate
Adsorption
Antioxidants
Capsules - chemistry
Catechin - administration & dosage
Catechin - analogs & derivatives
Chemistry
Colloidal state and disperse state
Drug Delivery Systems
EGCG
Electrochemistry
Electrophoresis
Exact sciences and technology
Gelatin
Gelatin - chemistry
Gelatin A/EGCG microcapsules
Gelatin/polyphenol assembly
General and physical chemistry
Layer-by-layer assembly
Membranes, Artificial
Permeability
Physical and chemical studies. Granulometry. Electrokinetic phenomena
Surface physical chemistry
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Summary:A new type of protein/polyphenol microcapsules on the basis of naturally occurring polyphenol (−)-epigallocatechin gallate (EGCG) and gelatin, type A, was obtained using the layer-by-layer (LbL) assembly method. The microcapsules show a more pronounced dependence of permeability on molecular weight of permeating substances than commonly used polyallylamine/polystyrene sulfonate capsules. The regularities of EGCG adsorption in alternation with type A and B gelatins have been investigated using quartz crystal microbalance and electrophoretic mobility measurements on microparticles and found to be dependent on gelatin properties. EGCG in the LbL assemblies retains its antioxidant activity. The kinetics of the reaction of 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) cation-radicals with films consisting of 1–10 gelatin/EGCG bilayers is affected by film structure. The EGCG content in the protein/polyphenol film material is as high as 30% w/w. Encapsulation of EGCG via its alternated adsorption with gelatins can be a perspective way to new formulations containing the polyphenol for drug delivery applications. Gelatin A/EGCG microcapsules possess antioxidant properties and show a pronounced dependence of permeability on molecular weight of permeating substance.
ISSN:0021-9797
1095-7103
DOI:10.1016/j.jcis.2008.10.082