Coexistence of myasthenia gravis and serological markers of neurological autoimmunity in neuromyelitis optica

We systematically evaluated the frequency of neurological disorders and muscle and neural autoantibodies in 177 patients with neuromyelitis optica (NMO) and in 250 control subjects (173 healthy; 77 multiple sclerosis, MS, patients). An excess of myasthenia gravis (MG, 2%), and muscle‐type acetylchol...

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Bibliographic Details
Published in:Muscle & nerve 2009-01, Vol.39 (1), p.87-90
Main Authors: McKeon, Andrew, Lennon, Vanda A., Jacob, Anu, Matiello, Marcelo, Lucchinetti, Claudia F., Kale, Nilufer, Chan, Koon H., Weinshenker, Brian G., Apiwattinakul, Metha, Wingerchuk, Dean M., Pittock, Sean J.
Format: Article
Language:English
Subjects:
acetylcholine receptor
Adolescent
Adult
Age Distribution
Aged
Aged, 80 and over
aquaporin-4
autoantibodies
Autoantibodies - blood
Autoimmunity - immunology
Biological and medical sciences
Biomarkers - analysis
Biomarkers - blood
Child
Child, Preschool
Comorbidity
Diseases of striated muscles. Neuromuscular diseases
Eye and associated structures. Visual pathways and centers. Vision
Female
Fundamental and applied biological sciences. Psychology
Humans
Male
Medical sciences
Middle Aged
multiple sclerosis
muscle
myasthenia gravis
Myasthenia Gravis - blood
Myasthenia Gravis - epidemiology
Myasthenia Gravis - immunology
neural
Neurology
Neuromuscular Junction - immunology
Neuromuscular Junction - physiopathology
neuromyelitis optica
Neuromyelitis Optica - blood
Neuromyelitis Optica - epidemiology
Neuromyelitis Optica - immunology
Receptors, Cholinergic - immunology
Sex Distribution
Vertebrates: nervous system and sense organs
water channel
Young Adult
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Summary:We systematically evaluated the frequency of neurological disorders and muscle and neural autoantibodies in 177 patients with neuromyelitis optica (NMO) and in 250 control subjects (173 healthy; 77 multiple sclerosis, MS, patients). An excess of myasthenia gravis (MG, 2%), and muscle‐type acetylcholine receptor antibody (11%) was detected among NMO patients. The presence of neural or muscle autoantibodies was more common in NMO patients (34%) than in MS patients or healthy controls (7%), P < 0.0001. The coexistence of NMO and MG should be considered in atypical or refractory presentations of either disorder. © 2008 Wiley Periodicals, Inc. Muscle Nerve 39: 87–90, 2009
ISSN:0148-639X
1097-4598
DOI:10.1002/mus.21197