Vancomycin-resistant enterococcus in pediatric oncology patients: An analysis of potential consequences of colonization and infection

A retrospective analysis of 57 pediatric oncology patients with a baseline positive vancomycin‐resistant enterococcus (VRE) culture who subsequently received chemotherapy and/or radiation therapy was performed. The incidence of subsequent VRE infection was calculated using a competing risk analysis...

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Bibliographic Details
Published in:Pediatric Blood & Cancer 2009-02, Vol.52 (2), p.300-302
Main Authors: Kosack, Amanda, Riedel, Elyn, Kiehn, Timothy E., Small, Trudy N., Wexler, Leonard H., Dunkel, Ira J.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Child
Child, Preschool
colonization
Enterococcus
Female
Humans
Incidence
Infant
infection
Male
mucositis
Neoplasms - complications
neutropenia
Retrospective Studies
Streptococcal Infections - etiology
Vancomycin Resistance
vancomycin-resistant enterococcus
Young Adult
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Summary:A retrospective analysis of 57 pediatric oncology patients with a baseline positive vancomycin‐resistant enterococcus (VRE) culture who subsequently received chemotherapy and/or radiation therapy was performed. The incidence of subsequent VRE infection was calculated using a competing risk analysis accounting for death from non‐VRE causes as a competing risk. Ten patients had subsequent VRE infection. The cumulative incidence of subsequent infection was 14% (7–27%, 95% confidence interval) at 1 year and 16% (9–29%, 95% confidence interval) at 2 years. None of the hypothesized risk factors appeared to differ between patients who developed a subsequent infection and those who did not. Pediatr Blood Cancer 2009;52:300–302. © 2008 Wiley‐Liss, Inc.
ISSN:1545-5009
1545-5017
1096-911X
DOI:10.1002/pbc.21793