Effect of biotic elicitors on the accumulation of bilobalide and ginkgolides in Ginkgo biloba cell cultures

The effect of biotic elicitors on the production of bilobalide and ginkgolides in Ginkgo biloba cell suspension cultures was studied. The treatment of cell cultures with Candida albicans and Staphylococcus aureus as elicitors increased the amounts of bilobalide (BB), ginkgolide A (GA) and ginkgolide...

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Bibliographic Details
Published in:Journal of biotechnology 2009, Vol.139 (1), p.84-88
Main Authors: Kang, Seung-Mi, Min, Ji-Yun, Kim, Yong-Duck, Karigar, C.S., Kim, Seon-Won, Goo, Gwan-Hyo, Choi, Myung-Suk
Format: Article
Language:English
Subjects:
Bilobalide
Biological and medical sciences
biosynthesis
Biotechnology
Biotic elicitor
biotic elicitors
Candida albicans
Cell Proliferation
Cell suspension culture
cell wall components
Cells, Cultured
culture media
Culture Media, Conditioned
Cyclopentanes - metabolism
Data Interpretation, Statistical
Fundamental and applied biological sciences. Psychology
Furans - metabolism
Ginkgo biloba
Ginkgo biloba - cytology
Ginkgo biloba - growth & development
Ginkgo biloba - metabolism
Ginkgolide A
Ginkgolide B
ginkgolides
Ginkgolides - metabolism
ginkogolide B
secondary metabolites
Sesquiterpenes
Staphylococcus aureus
Terpenes - metabolism
terpenoid lactones
Terpenoids
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Summary:The effect of biotic elicitors on the production of bilobalide and ginkgolides in Ginkgo biloba cell suspension cultures was studied. The treatment of cell cultures with Candida albicans and Staphylococcus aureus as elicitors increased the amounts of bilobalide (BB), ginkgolide A (GA) and ginkgolide B (GB), with slight growth inhibition. The native bacterial elicitor was more effective for secondary metabolite accumulations both in cells and culture medium than autoclaved. However, exposure times of the cells to the elicitors strongly influenced the production of BB, GA and GB. This study suggests that biotic elicitors can regulate the production of BB, GA and GB either directly or indirectly. These results also describe the establishment of optimum conditions that determine the effects of biotic elicitors on secondary metabolism of bilobalides.
ISSN:0168-1656
1873-4863
DOI:10.1016/j.jbiotec.2008.09.007