IgG Subclass Responses in Childhood Helicobacter pylori Duodenal Ulcer: Evidence of T-Helper Cell Type 2 Responses

ABSTRACT Background.  Duodenal ulcer in adults chronically infected with Helicobacter pylori is associated with a polarized T‐helper cell type 1 (Th1) mucosal immune response, with a predominantly immunoglobulin G2 (IgG2) systemic specific response. It has been suggested that children colonized by H...

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Bibliographic Details
Published in:Helicobacter (Cambridge, Mass.) Mass.), 2004-08, Vol.9 (4), p.289-292
Main Authors: Campbell, David I., Pearce, Mark S., Parker, Louise, Thomas, Julian E.
Format: Article
Language:English
Subjects:
Adult
Antibodies, Bacterial - blood
Biopsy
Child
Child, Preschool
duodenal ulcer
Duodenal Ulcer - immunology
Duodenal Ulcer - microbiology
Enzyme-Linked Immunosorbent Assay
Helicobacter Infections - complications
Helicobacter Infections - diagnosis
Helicobacter Infections - immunology
Helicobacter pylori
Helicobacter pylori - immunology
Humans
IgG subclass
Immunity, Mucosal
Immunoglobulin G - blood
Th2 Cells - immunology
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Summary:ABSTRACT Background.  Duodenal ulcer in adults chronically infected with Helicobacter pylori is associated with a polarized T‐helper cell type 1 (Th1) mucosal immune response, with a predominantly immunoglobulin G2 (IgG2) systemic specific response. It has been suggested that children colonized by H. pylori also produce a mucosal Th1 response, but there are few studies that have measured IgG subclass responses in children with duodenal ulcer. Materials and methods.  Seven children with endoscopically proven duodenal ulcer and H. pylori infection and 18 children with biopsy proven H. pylori infection but no duodenal ulcer had relative concentrations of IgG subclass responses (IgGsc) against H. pylori antigens measured by ELISA. Eighteen IgG seropositive adults acted as controls. The range of antigens recognised by IgG1 and IgG2 subclass responses were investigated by Western blots. Results.  There were no differences in mean IgGsc responses between children with or without duodenal ulcer. Adults produced an IgG2 predominant response. Western blots showed no qualitative differences in antigens recognised by IgG1 or IgG2. Conclusion.  Children with duodenal ulcer, in contrast to adults, produce an IgGsc response consistent with a mucosal Th2 response to H. pylori regardless of the presence of duodenal ulceration. This suggests that disease causation amongst children with H. pylori associated duodenal ulceration may not be dependant upon a mucosal Th1 biased response.
ISSN:1083-4389
1523-5378
DOI:10.1111/j.1083-4389.2004.00234.x