The malignant potential of endometrial polyps

Objectives: To determine the pre-malignant and malignant potential of endometrial polyps and to assess whether different clinical parameters are associated with malignancy in the polyps. Study design: Four hundred and thirty consecutive cases of hysteroscopic diagnosis of endometrial polyp were retr...

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Bibliographic Details
Published in:European journal of obstetrics & gynecology and reproductive biology 2004-08, Vol.115 (2), p.206-210
Main Authors: Ben-Arie, Alon, Goldchmit, Chen, Laviv, Yosef, Levy, Roni, Caspi, Benjamin, Huszar, Monica, Dgani, Ram, Hagay, Zion
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Cell Transformation, Neoplastic - pathology
Endometrial Neoplasms - diagnosis
Endometrial polyp
Female
Gynecology. Andrology. Obstetrics
Humans
Hysteroscopy
Malignancy
Medical sciences
Middle Aged
Polyps - diagnosis
Postmenopause
Precancerous Conditions - diagnosis
Predictive Value of Tests
Retrospective Studies
Risk Factors
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Summary:Objectives: To determine the pre-malignant and malignant potential of endometrial polyps and to assess whether different clinical parameters are associated with malignancy in the polyps. Study design: Four hundred and thirty consecutive cases of hysteroscopic diagnosis of endometrial polyp were retrieved. The medical records, preoperative vaginal sonography results and histopathology findings were reviewed. Statistical analysis was performed. Results: Hysteroscopy truly identified endometrial polyps in 95.7% of the cases. In 11.4% cases, hyperplasia without atypia was found in the endometrial polyp. In 3.3 and 3.0% of women pre-malignant or malignant conditions were found in the polyp. Older age, menopause status and polyps larger than 1.5 cm were associated with significant pre-malignant or malignant changes, although the positive predictive value for malignancy was low. All the malignant polyps were diagnosed only in postmenopausal women. The presence of postmenopausal or irregular vaginal bleeding, was not a predictor of malignancy in the polyp. Conclusions: Postmenopausal women with endometrial polyps are at increased risk of malignancy in the polyp. Those patients, whether symptomatic or not should be evaluated by hysteroscopic resection of the polyps. Asymptomatic premenopausal patients with polyps smaller than 1.5 cm can be observed.
ISSN:0301-2115
1872-7654
DOI:10.1016/j.ejogrb.2004.02.002