Thyroid peroxidase and galectin-3 immunostaining in differentiated thyroid carcinoma with clinicopathologic correlation

Summary Thyroperoxidase and galectin-3 have been reported as useful immunohistochemical markers of thyroid malignancy. In this study, we evaluated the relationship between immunohistochemical staining results for these markers and clinicopathologic features of patients with differentiated thyroid ca...

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Bibliographic Details
Published in:Human pathology 2008-11, Vol.39 (11), p.1656-1663
Main Authors: Savin, Svetlana, PhD, Cvejic, Dubravka, PhD, Isic, Tijana, BSc, Paunovic, Ivan, MD, PhD, Tatic, Svetislav, MD, PhD, Havelka, Marija, MD, PhD
Format: Article
Language:English
Subjects:
Adenocarcinoma, Follicular - metabolism
Adenocarcinoma, Follicular - pathology
Adenoma - metabolism
Adenoma - pathology
Adult
Biological and medical sciences
Biomarkers, Tumor - metabolism
Cancer
Carcinoma, Papillary - metabolism
Carcinoma, Papillary - pathology
Clinicopathologic
Endocrinopathies
Female
Galectin 3 - metabolism
Galectin-3
Humans
Immunohistochemistry
Investigative techniques, diagnostic techniques (general aspects)
Iodide Peroxidase - metabolism
Male
Malignant tumors
Medical sciences
Metabolic disorders
Middle Aged
Pathology
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Sensitivity and Specificity
Thyroid cancer
Thyroid carcinoma
Thyroid gland
Thyroid Gland - metabolism
Thyroid Gland - pathology
Thyroid Neoplasms - metabolism
Thyroid Neoplasms - pathology
Thyroid peroxidase
Thyroid. Thyroid axis (diseases)
Tumors
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Summary:Summary Thyroperoxidase and galectin-3 have been reported as useful immunohistochemical markers of thyroid malignancy. In this study, we evaluated the relationship between immunohistochemical staining results for these markers and clinicopathologic features of patients with differentiated thyroid cancer. A total of 193 archival thyroid samples including 28 follicular adenomas, 18 follicular carcinomas, and 147 papillary carcinomas with 114 adjacent thyroid tissues were analyzed by immunohistochemistry. Thyroperoxidase was underexpressed (5% stained thyrocytes) in most carcinomas. The sensitivity for diagnosis of differentiated thyroid carcinoma was 86.1% for thyroperoxidase and 82.4% for galectin-3, whereas the combination of both markers increased the sensitivity up to 94.5%. Thus, the combination of thyroperoxidase and galectin-3 immunohistochemistry may help to ascertain the malignant nature of the lesion. Furthermore, tumor size, nodal involvement, extrathyroidal invasion, and high tumor-node-metastasis stage in patients with papillary carcinoma were related to thyroperoxidase absence and high galectin-3 expression in most cases ( P < .05). In patients with follicular carcinoma, the extent of invasiveness was associated with galectin-3 positivity. Thus, expression of these markers is related to more or less aggressive biological behavior of differentiated thyroid carcinomas. Although thyroperoxidase presence may indicate favorable prognosis of papillary cancer, expression of galectin-3 illustrates the potential importance of this protein in the pathogenesis and/or progression of differentiated thyroid carcinomas.
ISSN:0046-8177
1532-8392
DOI:10.1016/j.humpath.2008.04.006