Perinatal Hypoxic and Ischemic Damage to the Central Nervous System Causes Changes in the Expression of Connexin 43 and CD38 and ADP-Ribosyl Cyclase Activity in Brain Cells

The expression of connexin 43 and CD38 and ADP ribosyl cyclase activity in brain cells were studied in rats with experimental hypoxic and ischemic damage to the CNS. Changes in the expression and activity of the enzyme were detected over the course of ischemic injury indicating a possible contributi...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2008-12, Vol.146 (6), p.733-736
Main Authors: Salmina, A. B, Malinovskaya, N. A, Okuneva, O. S, Taranushenko, T. E, Fursov, A. A, Mikhutkina, S. V, Morgun, A. V, Prokopenko, S. V, Zykova, L. D
Format: Article
Language:eng ; rus
Subjects:
ADP-ribosyl Cyclase - metabolism
ADP-ribosyl Cyclase 1 - metabolism
Animals
Animals, Newborn
Biomedical and Life Sciences
Biomedicine
Biophysics and Biochemistry
brain
Brain - metabolism
Brain - pathology
Brain Ischemia - physiopathology
CD38
Cell Biology
Central Nervous System - metabolism
Central Nervous System - pathology
connexin 43
Connexin 43 - metabolism
Gene Expression Regulation
Gene Expression Regulation, Enzymologic
Hypoxia - physiopathology
Immunohistochemistry
Internal Medicine
Laboratory Medicine
Pathology
perinatal hypoxia/ischemia
Rats
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Summary:The expression of connexin 43 and CD38 and ADP ribosyl cyclase activity in brain cells were studied in rats with experimental hypoxic and ischemic damage to the CNS. Changes in the expression and activity of the enzyme were detected over the course of ischemic injury indicating a possible contribution of NAD⁺-converting activity and NAD⁺-transporting processes to the pathogenesis of acute cerebral ischemic injury.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-009-0385-6