Nuclear Medicine in the Era of Genomics and Proteomics:  Lessons from Annexin V

In the past decade, genomics and proteomics have begun to develop many new targets for potential diagnostic and therapeutic agents. Among the life sciences, nuclear medicine is also deeply involved in the field of clinical investigation. Experience with radiolabeled annexin V highlights the many ste...

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Bibliographic Details
Published in:Journal of proteome research 2004-05, Vol.3 (3), p.345-349
Main Authors: Belhocine, Tarik Z, Tait, Jonathan F, Vanderheyden, Jean-Luc, Li, Chun, Blankenberg, Francis G
Format: Article
Language:English
Subjects:
Annexin A5 - chemistry
Annexin A5 - pharmacokinetics
Apoptosis - physiology
Humans
Isotope Labeling
Kidney - diagnostic imaging
Liver - diagnostic imaging
Models, Molecular
Nuclear Medicine
Radionuclide Imaging
Spleen - diagnostic imaging
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Summary:In the past decade, genomics and proteomics have begun to develop many new targets for potential diagnostic and therapeutic agents. Among the life sciences, nuclear medicine is also deeply involved in the field of clinical investigation. Experience with radiolabeled annexin V highlights the many steps required to translate a good basic-science concept into the clinical setting. This model also emphasizes the value of synergy between basic and medical specialties in developing and optimizing a clinically useful product initially derived from basic investigation. Keywords: annexin V • recombinant human • radiolabeling • apoptosis
ISSN:1535-3893
1535-3907
DOI:10.1021/pr049968a