Pulmonary Vein Isolation for Atrial Fibrillation in Patients with Symptomatic Sinus Bradycardia or Pauses

Introduction: Sick sinus syndrome is commonly associated with tachyarrhythmias and bradyarrhythmias that often are symptomatic. The aim of this study was to assess the effect of pulmonary vein isolation in patients with sick sinus syndrome and atrial fibrillation (AF). Methods and Results: Three hun...

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Published in:Journal of cardiovascular electrophysiology 2004-07, Vol.15 (7), p.784-789
Main Authors: KHAYKIN, YAARIV, MARROUCHE, NASSIR F., MARTIN, DAVID O., SALIBA, WALID, SCHWEIKERT, ROBERT, WEXMAN, MARK, STRUNK, BRIAN, BEHEIRY, SALWA, SAAD, EDUARDO, BHARGAVA, MANDEEP, BURKHARDT, J. DAVID, JOSEPH, GEORGE, TCHOU, PATRICK, NATALE, ANDREA
Format: Article
Language:English
Subjects:
Analysis of Variance
atrial fibrillation
Atrial Fibrillation - etiology
Atrial Fibrillation - physiopathology
Atrial Fibrillation - surgery
Catheter Ablation
Chi-Square Distribution
Electrocardiography
Female
Humans
Male
Middle Aged
Pacemaker, Artificial
pulmonary vein isolation
Pulmonary Veins
Recurrence
sick sinus syndrome
Sick Sinus Syndrome - complications
Sick Sinus Syndrome - physiopathology
Sick Sinus Syndrome - surgery
Treatment Outcome
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Summary:Introduction: Sick sinus syndrome is commonly associated with tachyarrhythmias and bradyarrhythmias that often are symptomatic. The aim of this study was to assess the effect of pulmonary vein isolation in patients with sick sinus syndrome and atrial fibrillation (AF). Methods and Results: Three hundred fourteen consecutive patients who underwent pulmonary vein isolation between December 2000 and January 2002 were included in the study. Thirty‐one patients had sick sinus syndrome, which was defined as a preprocedural history of symptomatic sinus bradycardia or pauses. Endpoints included AF recurrence, change in the frequency of sinus pauses, and symptoms of presyncope or syncope, as well as mean heart rate and percentage of atrial pacing in patients with pacemakers implanted prior to the pulmonary vein isolation. Patients had AF for an average of 6 ± 3 years. Patients were 58 ±8 years old and had ejection fractions of 55 ± 4%. Sixty‐one percent had implanted pacemakers. AF recurred within 6 months in 4 patients. Two had a successful second pulmonary vein isolation procedure. There were no recurrences of presyncopal events (P 
ISSN:1045-3873
1540-8167
DOI:10.1046/j.1540-8167.2004.03279.x