Prevalence of drug-induced electrocardiographic pattern of the Brugada syndrome in a healthy population

To determine the prevalence of drug-induced Brugada's syndrome (BrS) electrocardiograms (ECGs) in a healthy population, a sodium channel blockade challenge was performed in previously identified subjects with BrS-compatible (BrC) ECGs. These subjects were detected in 1,000 normal patients in wh...

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Bibliographic Details
Published in:The American journal of cardiology 2004-07, Vol.94 (2), p.230-233
Main Authors: Hermida, Jean-Sylvain, Jandaud, Serge, Lemoine, Jean-Luc, Rodriguez-Lafrasse, Claire, Delonca, Jean, Bertrand, Cathy, Jarry, Geneviève, Rochette, Jacques, Rey, Jean-Luc
Format: Article
Language:English
Subjects:
Adult
Ajmaline - pharmacology
Anti-Arrhythmia Agents - pharmacology
Biological and medical sciences
Bundle-Branch Block - epidemiology
Bundle-Branch Block - genetics
Cardiac dysrhythmias
Cardiology
Cardiology. Vascular system
Drug use
Electrocardiography
Female
Health
Heart
Humans
Male
Medical sciences
NAV1.5 Voltage-Gated Sodium Channel
Polymorphism, Single-Stranded Conformational
Population
Prospective Studies
Sodium Channels - drug effects
Sodium Channels - genetics
Syndrome
Ventricular Fibrillation - epidemiology
Ventricular Fibrillation - genetics
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Summary:To determine the prevalence of drug-induced Brugada's syndrome (BrS) electrocardiograms (ECGs) in a healthy population, a sodium channel blockade challenge was performed in previously identified subjects with BrS-compatible (BrC) ECGs. These subjects were detected in 1,000 normal patients in whom first ECGs were systematically recorded. Because of the intermittent nature of electrocardiographic modifications in BrS, second ECGs were also recorded in a representative sample of the population presenting with first ECGs with normal results. The prevalence of typical drug-induced BrS ECGs was 5 of the 1,000 patients. This value was fivefold greater than the reported prevalence of spontaneous BrS ECGs in the healthy population.
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2004.03.072