Physiology: does gut hormone PYY3-36 decrease food intake in rodents?

Batterham et al. report that the gut peptide hormone PYY3-36 decreases food intake and body-weight gain in rodents, a discovery that has been heralded as potentially offering a new therapy for obesity. However, we have been unable to replicate their results. Although the reasons for this discrepancy...

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Bibliographic Details
Published in:Nature 2004-07, Vol.430 (6996), p.1 p following 165; discussion 2 p following 165-1 p following 165; discussion 2 p following 165
Main Authors: Tschöp, M, Castañeda, T R, Joost, H G, Thöne-Reineke, C, Ortmann, S, Klaus, S, Hagan, M M, Chandler, P C, Oswald, K D, Benoit, S C, Seeley, R J, Kinzig, K P, Moran, T H, Beck-sickinger, A G, Koglin, N, Rodgers, R J, Blundell, J E, Ishii, Y, Beattie, A H, Holch, P, Allison, D B, Raun, K, Madsen, K, Wulff, B S, Stidsen, C E, Birringer, M, Kreuzer, O J, Schindler, M, Arndt, K, Rudolf, K, Mark, M, Deng, X Y, Whitcomb, D C, Halem, H, Taylor, J, Dong, J, Datta, R, Culler, M, Craney, S, Flora, D, Smiley, D, Heiman, M L, Withcomb, D C
Format: Article
Language:English
Subjects:
Animals
Animals, Inbred Strains
Appetite - drug effects
Appetite - physiology
Appetite Depressants - pharmacology
Appetite Depressants - therapeutic use
Appetite Regulation - drug effects
Behavior, Animal - drug effects
Body Weight - drug effects
Environment
Feeding Behavior - drug effects
Humans
Meta-Analysis as Topic
Mice
Obesity - drug therapy
Peptide Fragments
Peptide YY - administration & dosage
Peptide YY - blood
Peptide YY - pharmacology
Peptide YY - therapeutic use
Rats
Reproducibility of Results
Stress, Physiological - complications
Stress, Physiological - physiopathology
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Summary:Batterham et al. report that the gut peptide hormone PYY3-36 decreases food intake and body-weight gain in rodents, a discovery that has been heralded as potentially offering a new therapy for obesity. However, we have been unable to replicate their results. Although the reasons for this discrepancy remain undetermined, an effective anti-obesity drug ultimately must produce its effects across a range of situations. The fact that the findings of Batterham et al. cannot easily be replicated calls into question the potential value of an anti-obesity approach that is based on administration of PYY3-36.
ISSN:0028-0836
1476-4687
DOI:10.1038/nature02666a