Literature-related discovery (LRD): Lessons learned, and future research directions

Literature-related discovery (LRD): Lessons learned, and future research directions

Literature-related discovery (LRD) is the linking of two or more literature concepts that have heretofore not been linked (i.e., disjoint), in order to produce novel, interesting, plausible, and intelligible knowledge (i.e., potential discovery). The open discovery systems (ODS) component of LRD sta...

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Bibliographic Details
Published in:Technological forecasting & social change 2008-02, Vol.75 (2), p.276-299
Main Authors: Kostoff, Ronald N., Block, Joel A., Solka, Jeffrey L., Briggs, Michael B., Rushenberg, Robert L., Stump, Jesse A., Johnson, Dustin, Lyons, Terence J., Wyatt, Jeffrey R.
Format: Article
Language:eng
Subjects:
Cataracts
Innovation
Innovations
Literature
Literature-based discovery
Medical treatment
Multiple Sclerosis
Parkinson's Disease
Problem solving
Raynaud's Phenomenon
Research Methodology
Studies
Text mining
Water purification
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Summary:Literature-related discovery (LRD) is the linking of two or more literature concepts that have heretofore not been linked (i.e., disjoint), in order to produce novel, interesting, plausible, and intelligible knowledge (i.e., potential discovery). The open discovery systems (ODS) component of LRD starts with a problem to be solved, and generates solutions to that problem through potential discovery. We have been using ODS LRD to identify potential treatments or preventative actions for challenging medical problems, among myriad other applications. The five immediately preceding papers in this Special Issue describe the application of ODS LRD to Raynaud's Phenomenon (RP), cataracts, Parkinson's Disease (PD), Multiple Sclerosis (MS), and Water Purification (WP). We describe the lessons learned from each application, and how the techniques can be improved further. Generation of much potential discovery using ODS LRD is possible when the conceptual roadblocks to discovery are removed. Some of these roadblocks include use of numerical filters that are unrelated to generating discovery, and excessive reliance on literatures directly related to the problem literature of interest. The issue of how to handle large amounts of potential discovery has not been addressed in the literature, since most ODS LRD researchers have tried to find a relatively few potential discovery items. We present a development strategy that capitalizes on the large amounts of potential discovery we have identified.
ISSN:0040-1625
1873-5509