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Intestinal Permeability and Glucagon-like peptide-2 in Children with Autism: A Controlled Pilot Study
We measured small intestinal permeability using a lactulose:mannitol sugar permeability test in a group of children with autism, with current or previous gastrointestinal complaints. Secondly, we examined whether children with autism had an abnormal glucagon-like peptide-2 (GLP-2) response to feedin...
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Published in: | Journal of autism and developmental disorders 2008-07, Vol.38 (6), p.1066-1071 |
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container_end_page | 1071 |
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container_title | Journal of autism and developmental disorders |
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creator | Robertson, Marli A. Sigalet, David L. Holst, Jens J. Meddings, Jon B. Wood, Julie Sharkey, Keith A. |
description | We measured small intestinal permeability using a lactulose:mannitol sugar permeability test in a group of children with autism, with current or previous gastrointestinal complaints. Secondly, we examined whether children with autism had an abnormal glucagon-like peptide-2 (GLP-2) response to feeding. Results were compared with sibling controls and children without developmental disabilities. We enrolled 14 children with autism, 7 developmentally normal siblings of these children and 8 healthy, developmentally normal, unrelated children. Our study did not detect differences in these measures of gastrointestinal function in a group of children with autism. |
doi_str_mv | 10.1007/s10803-007-0482-1 |
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Secondly, we examined whether children with autism had an abnormal glucagon-like peptide-2 (GLP-2) response to feeding. Results were compared with sibling controls and children without developmental disabilities. We enrolled 14 children with autism, 7 developmentally normal siblings of these children and 8 healthy, developmentally normal, unrelated children. Our study did not detect differences in these measures of gastrointestinal function in a group of children with autism.</description><identifier>ISSN: 0162-3257</identifier><identifier>EISSN: 1573-3432</identifier><identifier>DOI: 10.1007/s10803-007-0482-1</identifier><identifier>PMID: 18311517</identifier><identifier>CODEN: JADDDQ</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Autism ; Autistic children ; Autistic Disorder - diagnosis ; Autistic Disorder - physiopathology ; Autistic Disorder - psychology ; Behavioral Science and Psychology ; Biological and medical sciences ; Biological markers ; Biophysics ; Brain ; Child ; Child and School Psychology ; Child clinical studies ; Child Health ; Child, Preschool ; Comparative Analysis ; Developmental Disabilities ; Developmental disorders ; Etiology ; Female ; Glucagon-Like Peptide 2 - blood ; Hospitals ; Human Body ; Humans ; Infantile autism ; Intestinal Absorption - physiology ; Intestinal disorders ; Intestine, Small - physiopathology ; Lactulose - metabolism ; Male ; Mannitol - metabolism ; Measurement Techniques ; Medical Evaluation ; Medical sciences ; Neurosciences ; Nutrition ; Original Paper ; Pediatrics ; Physical Examinations ; Physiology ; Pilot Projects ; Psychology ; Psychology. 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Secondly, we examined whether children with autism had an abnormal glucagon-like peptide-2 (GLP-2) response to feeding. Results were compared with sibling controls and children without developmental disabilities. We enrolled 14 children with autism, 7 developmentally normal siblings of these children and 8 healthy, developmentally normal, unrelated children. 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Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>Journal of autism and developmental disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Robertson, Marli A.</au><au>Sigalet, David L.</au><au>Holst, Jens J.</au><au>Meddings, Jon B.</au><au>Wood, Julie</au><au>Sharkey, Keith A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><ericid>EJ797503</ericid><atitle>Intestinal Permeability and Glucagon-like peptide-2 in Children with Autism: A Controlled Pilot Study</atitle><jtitle>Journal of autism and developmental disorders</jtitle><stitle>J Autism Dev Disord</stitle><addtitle>J Autism Dev Disord</addtitle><date>2008-07-01</date><risdate>2008</risdate><volume>38</volume><issue>6</issue><spage>1066</spage><epage>1071</epage><pages>1066-1071</pages><issn>0162-3257</issn><eissn>1573-3432</eissn><coden>JADDDQ</coden><abstract>We measured small intestinal permeability using a lactulose:mannitol sugar permeability test in a group of children with autism, with current or previous gastrointestinal complaints. Secondly, we examined whether children with autism had an abnormal glucagon-like peptide-2 (GLP-2) response to feeding. Results were compared with sibling controls and children without developmental disabilities. We enrolled 14 children with autism, 7 developmentally normal siblings of these children and 8 healthy, developmentally normal, unrelated children. Our study did not detect differences in these measures of gastrointestinal function in a group of children with autism.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>18311517</pmid><doi>10.1007/s10803-007-0482-1</doi><tpages>6</tpages></addata></record> |
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subjects | Autism Autistic children Autistic Disorder - diagnosis Autistic Disorder - physiopathology Autistic Disorder - psychology Behavioral Science and Psychology Biological and medical sciences Biological markers Biophysics Brain Child Child and School Psychology Child clinical studies Child Health Child, Preschool Comparative Analysis Developmental Disabilities Developmental disorders Etiology Female Glucagon-Like Peptide 2 - blood Hospitals Human Body Humans Infantile autism Intestinal Absorption - physiology Intestinal disorders Intestine, Small - physiopathology Lactulose - metabolism Male Mannitol - metabolism Measurement Techniques Medical Evaluation Medical sciences Neurosciences Nutrition Original Paper Pediatrics Physical Examinations Physiology Pilot Projects Psychology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Public Health Reference Values Research Assistants Satiety Response - physiology Siblings Verbal Communication |
title | Intestinal Permeability and Glucagon-like peptide-2 in Children with Autism: A Controlled Pilot Study |
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