Intestinal Permeability and Glucagon-like peptide-2 in Children with Autism: A Controlled Pilot Study

We measured small intestinal permeability using a lactulose:mannitol sugar permeability test in a group of children with autism, with current or previous gastrointestinal complaints. Secondly, we examined whether children with autism had an abnormal glucagon-like peptide-2 (GLP-2) response to feedin...

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Bibliographic Details
Published in:Journal of autism and developmental disorders 2008-07, Vol.38 (6), p.1066-1071
Main Authors: Robertson, Marli A., Sigalet, David L., Holst, Jens J., Meddings, Jon B., Wood, Julie, Sharkey, Keith A.
Format: Article
Language:English
Subjects:
Autism
Autistic children
Autistic Disorder - diagnosis
Autistic Disorder - physiopathology
Autistic Disorder - psychology
Behavioral Science and Psychology
Biological and medical sciences
Biological markers
Biophysics
Brain
Child
Child and School Psychology
Child clinical studies
Child Health
Child, Preschool
Comparative Analysis
Developmental Disabilities
Developmental disorders
Etiology
Female
Glucagon-Like Peptide 2 - blood
Hospitals
Human Body
Humans
Infantile autism
Intestinal Absorption - physiology
Intestinal disorders
Intestine, Small - physiopathology
Lactulose - metabolism
Male
Mannitol - metabolism
Measurement Techniques
Medical Evaluation
Medical sciences
Neurosciences
Nutrition
Original Paper
Pediatrics
Physical Examinations
Physiology
Pilot Projects
Psychology
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Public Health
Reference Values
Research Assistants
Satiety Response - physiology
Siblings
Verbal Communication
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Description
Summary:We measured small intestinal permeability using a lactulose:mannitol sugar permeability test in a group of children with autism, with current or previous gastrointestinal complaints. Secondly, we examined whether children with autism had an abnormal glucagon-like peptide-2 (GLP-2) response to feeding. Results were compared with sibling controls and children without developmental disabilities. We enrolled 14 children with autism, 7 developmentally normal siblings of these children and 8 healthy, developmentally normal, unrelated children. Our study did not detect differences in these measures of gastrointestinal function in a group of children with autism.
ISSN:0162-3257
1573-3432
DOI:10.1007/s10803-007-0482-1