Isolation and identification of an endophytic strain of Fusarium oxysporum producing podophyllotoxin from Juniperus recurva

Podophyllotoxin, a well-known naturally occurring aryltetralin lignan occurs in few plant species that is used as a precursor for the chemical synthesis of the anticancer drugs like etoposide, teniposide and etopophose phosphate. The availiability of this lignan is becoming increasingly limited beca...

Full description

Saved in:
Bibliographic Details
Published in:World journal of microbiology & biotechnology 2008-07, Vol.24 (7), p.1115-1121
Main Authors: Kour, Amardeep, Shawl, Abdul S, Rehman, Suriya, Sultan, Phalisteen, Qazi, Parvaiz H, Suden, Pankaj, Khajuria, Ravi K, Verma, Vijeshwar
Format: Article
Language:English
Subjects:
Applied Microbiology
Biochemistry
Biological and medical sciences
Biological products
Biomedical and Life Sciences
Biotechnology
Cancer
Chemical synthesis
Chromatography
Endangered & extinct species
Environmental Engineering/Biotechnology
Flowers & plants
Fundamental and applied biological sciences. Psychology
Fungi
Fusarium oxysporum
Herbal medicine
Integrative medicine
Juniperus
Life Sciences
Microbiology
Original Paper
Studies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Podophyllotoxin, a well-known naturally occurring aryltetralin lignan occurs in few plant species that is used as a precursor for the chemical synthesis of the anticancer drugs like etoposide, teniposide and etopophose phosphate. The availiability of this lignan is becoming increasingly limited because of the scarce occurance of its natural sources and also because synthetic approaches for its production are still commercially unacceptable. This paper reports first time the production of podophyllotoxin by an endophytic fungus Fusarium oxysporum isolated from the medicinal plant Juniperus recurva. Further confirmation and quantification of podophyllotoxin was performed by HPLC, LC-MS, and LC-MS/MS.
ISSN:0959-3993
1573-0972
DOI:10.1007/s11274-007-9582-5