The (beta gamma) Subunits of GTP-Binding Proteins Activate the Muscarinic K(plus) Channel in Heart

Subunits of guanine nucleotide regulatory proteins purified from bovine cerebral cortex were used to perfuse the intracellular surface of excised patches of chick embryonic atrial cells. Single-channel current measurements unexpectedly indicate that the beta gamma, and not the alpha subunits, are re...

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Bibliographic Details
Published in:Nature (London) 1987-01, Vol.325 (6102), p.321-321
Main Authors: Clapham, David E, Neer, Eva J, Galper, Jonas, Kurachi, Yoshihisa, Logothetis, Diomedes E
Format: Article
Language:English
Subjects:
Biochemistry
Medical research
Proteins
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Summary:Subunits of guanine nucleotide regulatory proteins purified from bovine cerebral cortex were used to perfuse the intracellular surface of excised patches of chick embryonic atrial cells. Single-channel current measurements unexpectedly indicate that the beta gamma, and not the alpha subunits, are responsible for activating the muscarinic-gated potassium channel.
ISSN:0028-0836
1476-4687