Genotoxic biomonitoring of agricultural workers exposed to pesticides in the north of Sinaloa State, Mexico

Genotoxic damage was evaluated in 70 agricultural workers, 25 women and 45 men, exposed to pesticides in Las Grullas, Ahome, Sinaloa, Mexico, with an average of 7 years of exposure. The effect was detected through the sister chromatid exchanges (SCE) in lymphocytes of peripheral blood and micronucle...

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Bibliographic Details
Published in:Environment international 2009-11, Vol.35 (8), p.1155-1159
Main Authors: Martínez-Valenzuela, Carmen, Gómez-Arroyo, Sandra, Villalobos-Pietrini, Rafael, Waliszewski, Stefan, Calderón-Segura, María Elena, Félix-Gastélum, Rubén, Álvarez-Torres, Armando
Format: Article
Language:English
Subjects:
Adult
Agricultural chemicals
Agriculture
Biological and medical sciences
Buccal exfoliated cells
Cell Proliferation - drug effects
Cell proliferation kinetics
Cellular
Damage
Environmental Monitoring
Environmental Pollutants - blood
Environmental Pollutants - toxicity
Exposure
Female
Genotoxicity
Human lymphocytes
Humans
Lymphocytes - drug effects
Male
Medical sciences
Men
Mexico
Micronuclei
Middle Aged
Mitotic Index
Mutagens - metabolism
Mutagens - toxicity
Occupational Exposure - analysis
Pesticide exposure
Pesticides
Pesticides - blood
Pesticides - toxicity
Pesticides, fertilizers and other agrochemicals toxicology
Risk
Sister chromatid exchange
Sister Chromatid Exchange - drug effects
Toxicology
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Summary:Genotoxic damage was evaluated in 70 agricultural workers, 25 women and 45 men, exposed to pesticides in Las Grullas, Ahome, Sinaloa, Mexico, with an average of 7 years of exposure. The effect was detected through the sister chromatid exchanges (SCE) in lymphocytes of peripheral blood and micronuclei (MN) and other nuclear anomalies (NA) in buccal exfoliated cells. Also, the influence on cellular proliferation kinetics (CPK) was studied by means of the replication index (RI) and the cytotoxic effect was examined with the mitotic index (MI). The non-exposed group consisted of 70 other persons, 21 women and 47 men from the city of Los Mochis, Sinaloa, Mexico. Significant differences between the exposed and the non-exposed groups were observed in SCE, CPK, MI, MN and NA. Analysis of variance revealed that age, gender, smoking and alcohol consumption did not have a significant effect on genetic damage. However, there was a correlation between exposure time to pesticides and SCE frequency. These results could have been due to the exposure of workers to pesticides containing different chemical compounds. This study afforded valuable data to estimate the possible risk to health associated with pesticide exposure.
ISSN:0160-4120
1873-6750
DOI:10.1016/j.envint.2009.07.010