Relaxin as a Protective Substance in the Preserving Solution for Liver Transplantation

Ischemia reperfusion injury (IRI) is a problem in organ transplantation. Relaxin is known to have a protective effect against liver injury caused by IRI. Using a model of isolated perfused rat liver, the local oxygen supply in liver tissue was investigated by spectrophotometric in vivo imaging and c...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2009-04, Vol.1160 (1), p.320-321
Main Authors: Boehnert, Markus U., Armbruster, Franz Paul, Hilbig, Heidegard
Format: Article
Language:English
Subjects:
imaging
ischemia reperfusion injury
liver
relaxin
transplantation
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Summary:Ischemia reperfusion injury (IRI) is a problem in organ transplantation. Relaxin is known to have a protective effect against liver injury caused by IRI. Using a model of isolated perfused rat liver, the local oxygen supply in liver tissue was investigated by spectrophotometric in vivo imaging and compared to the protective effect of relaxin shown by immunohistochemical measurement of myeloperoxidase and malonyldialdehyde activities as determinants of oxidative stress. In relaxin‐treated liver tissue, spectrophotometry showed a better oxygen supply and decreased myeloperoxidase and malonyldialdehyde activities. Our data suggest that relaxin can influence the oxygen distribution in liver tissue and reduce cell damage caused by IRI.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.2008.03804.x