Preparation and characterization of venlafaxine hydrochloride-loaded chitosan nanoparticles and in vitro release of drug

The venlafaxine hydrochloride (VHL)-loaded chitosan nanoparticles were prepared by ionic gelation of chitosan (CS) using tripolyphosphate (TPP). The nanoparticles were characterized using FTIR, differential scanning calorimetry, X-ray diffraction, dynamic light scattering, transmission electron micr...

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Bibliographic Details
Published in:Journal of applied polymer science 2009-06, Vol.112 (5), p.2876-2887
Main Authors: Shah, Sunil, Pal, Angshuman, Kaushik, V.K, Devi, Surekha
Format: Article
Language:English
Subjects:
Applied sciences
Biological and medical sciences
chitosan
Exact sciences and technology
General pharmacology
ionic gelation
Medical sciences
nanoparticles
Organic polymers
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Physicochemistry of polymers
Properties and characterization
Thermal and thermodynamic properties
venlafaxine hydrochloride
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Summary:The venlafaxine hydrochloride (VHL)-loaded chitosan nanoparticles were prepared by ionic gelation of chitosan (CS) using tripolyphosphate (TPP). The nanoparticles were characterized using FTIR, differential scanning calorimetry, X-ray diffraction, dynamic light scattering, transmission electron microscopy, and X-ray photoelectron spectroscopy. The effect of concentration of CS, polyethylene glycol (PEG), VHL and CS/TPP mass ratio on the particle size and zeta potential of nanoparticles was examined. The particle size of CS/TPP nanoparticles and VHL-loaded CS/TPP nanoparticles was within the range of 200-400 nm with positive surface charge. In the case of VHL-loaded nanoparticles and PEG-coated CS/TPP nanoparticles, the particle size increases and surface charge decreases with increasing concentration of VHL and PEG. Both placebo and VHL-loaded CS/TPP nanoparticles were observed to be spherical in nature. PEG coating on the surface of CS/TPP nanoparticles was confirmed by XPS analysis. Maximum drug entrapment efficiency (70%) was observed at 0.6 mg/mL drug concentration. In vitro drug release study at 37°C ± 0.5°C and pH 7.4 exhibited initial burst release followed by a steady release.
ISSN:0021-8995
1097-4628
DOI:10.1002/app.29807