Solid lipid nanoparticles for parenteral drug delivery

This review describes the use of nanoparticles based on solid lipids for the parenteral application of drugs. Firstly, different types of nanoparticles based on solid lipids such as “solid lipid nanoparticles” (SLN), “nanostructured lipid carriers” (NLC) and “lipid drug conjugate” (LDC) nanoparticle...

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Bibliographic Details
Published in:Advanced drug delivery reviews 2004-05, Vol.56 (9), p.1257-1272
Main Authors: Wissing, S.A, Kayser, O, Müller, R.H
Format: Article
Language:English
Subjects:
Animals
Chemistry, Pharmaceutical
Degradation
Drug Carriers - adverse effects
Drug Carriers - chemistry
Drug Carriers - pharmacokinetics
Excipients - adverse effects
Excipients - chemistry
Excipients - pharmacokinetics
Injections, Intramuscular
Injections, Intravenous
Injections, Subcutaneous
LDC
Lipids - adverse effects
Lipids - chemistry
Lipids - pharmacokinetics
Nanotechnology
NLC
Parenterals
Particle Size
Pharmaceutical Preparations - administration & dosage
Pharmaceutical Preparations - chemistry
Pharmaceutical Preparations - metabolism
Pharmacokinetics
SLN
Solid lipid nanoparticles
Toxicity
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Summary:This review describes the use of nanoparticles based on solid lipids for the parenteral application of drugs. Firstly, different types of nanoparticles based on solid lipids such as “solid lipid nanoparticles” (SLN), “nanostructured lipid carriers” (NLC) and “lipid drug conjugate” (LDC) nanoparticles are introduced and structural differences are pointed out. Different production methods including the suitability for large scale production are described. Stability issues and drug incorporation mechanisms into the particles are discussed. In the second part, the biological activity of parenterally applied SLN and biopharmaceutical aspects such as pharmacokinetic profiles as well as toxicity aspects are reviewed.
ISSN:0169-409X
1872-8294
DOI:10.1016/j.addr.2003.12.002