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Drug-Eluting Coronary Stents Coated with Polysulfone-Poly(ethylene Oxide) Block Copolymer by Ultrasonic Spray
Amphiphilic polysulfone-poly(ethylene oxide) block copolymers (PSF-b-PEOs) with different contents of PEO, have been successfully synthesized and employed as the drug carrier for use in drug-eluting stent (DES) systems. They are well soluble in organic solvents such as tetrahydrofuran (THF). Cell gr...
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Published in: | Key engineering materials 2008-01, Vol.373-374, p.633-636 |
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Main Authors: | , , , |
Format: | Article |
Language: | English |
Citations: | Items that cite this one |
Online Access: | Get full text |
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Summary: | Amphiphilic polysulfone-poly(ethylene oxide) block copolymers (PSF-b-PEOs) with
different contents of PEO, have been successfully synthesized and employed as the drug carrier for
use in drug-eluting stent (DES) systems. They are well soluble in organic solvents such as
tetrahydrofuran (THF). Cell growth, hemolysis, cell hyperplasia, toxicity and sensitization tests
revealed that PSF-b-PEOs have good biocompatibility. Silolimus was selected as the drug and the
loading level was controlled at 10 or 20 wt%. PSF-b-PEO-coated stents were fabricated by the widely
used ultrasonic spray coating technique. Pre- and post-expansion morphologies of the coatings were
observed by optical microscopy (OM) and scanning electron microscopy (SEM). Under the optimal
operation conditions, the stents have uniform and smooth coating surface. No cracks or peels were
observed when the coating stents were expanded. No drug particles were observed on the stent
surface. PEO content in PSF-b-PEOs greatly influences drug release rate, and the higher the PEO
content, the faster the release rate. PSF-b-PEO film comprising 30% PEO displayed relatively
reasonable drug release rate, i.e., about 80% silolimus were released from the film after release tests in
phosphate buffer solutions (PH = 7.4) containing 10 v% ethanol at 37 °C for 24 days. |
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ISSN: | 1013-9826 1662-9795 1662-9795 |
DOI: | 10.4028/www.scientific.net/KEM.373-374.633 |