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Biocompatibility Evaluation of Porous Si-Containing Hydroxyapatite Derived from Coral
A porous silicon-containing hydroxyapatite has been prepared using natural coral as a calcium source to obtain a biomaterial having an improved biocompatibility. From the XRD analysis, it was confirmed that the single-phase hydroxyapatite containing silicon has formed without revealing the presence...
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Published in: | Key engineering materials 2008-01, Vol.361-363, p.131-134 |
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Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | A porous silicon-containing hydroxyapatite has been prepared using natural coral as a
calcium source to obtain a biomaterial having an improved biocompatibility. From the XRD
analysis, it was confirmed that the single-phase hydroxyapatite containing silicon has formed
without revealing the presence of extra phases related to silicon dioxide or other calcium phosphate
species. Silicon content is ranged from 0.5wt% to 1wt% by weight. The porous silicon-containing
hydroxyapatite blocks were inserted into the 5mm diameter of drill holes made through the lateral
femoral condyles of New Zealand white rabbits. The new bony formation did not begin after 1
week. At 3 week, bony ongrowth to the inserted porous silicon-containing hydroxyapatite block
could be found, and the new bone surrounded the inserted block entirely after 24weeks. Based on
in-vivo test, Si-containing porous hydroxyapatite derived from coral possesses high biodegradability
and can be considered a useful material for bone implants. |
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ISSN: | 1013-9826 1662-9795 1662-9795 |
DOI: | 10.4028/www.scientific.net/KEM.361-363.131 |