Cobalt (II) porphyrin nanoaggregates as sacrificial templates to improve the peroxidase-like activity of light-controlled TiO2-based nanozymes for colorimetric determination of amikacin

Although porphyrin modification can improve the peroxidase-like activity of some inorganic nanozymes, it is hardly studied that metal porphyrin self-assembled nanoaggregates as sacrificial templates to turn on the peroxidase-like activity of inorganic nanozymes under light illumination. In this work...

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Bibliographic Details
Published in:Talanta (Oxford) 2025-01, Vol.281, p.126889, Article 126889
Main Authors: Wang, Liming, Chu, Ying, Cao, Bo, Zhang, Ruizhe, Hussain, Zakir, Liu, Qingyun
Format: Article
Language:English
Subjects:
Amikacin
Colorimetric sensing
Light-controlled nanozyme
Peroxidase
Porphyrin aggregate
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Summary:Although porphyrin modification can improve the peroxidase-like activity of some inorganic nanozymes, it is hardly studied that metal porphyrin self-assembled nanoaggregates as sacrificial templates to turn on the peroxidase-like activity of inorganic nanozymes under light illumination. In this work, cobalt (II) 5,10,15,20-Tetrakis (4-carboxylpheyl)porphyrin (CoTCPP) self-assembled nanoaggregates are firstly used as soft templates to prepare TiO2-based nanozymes with the enhanced peroxidase-like activity. Interestingly, CoTCPP nanoaggregates can be changed into Co oxide nanoparticles dispersed into the nanosphere composites. Furthermore, the peroxidase-like activity of CoTCPP-TiO2 nanospheres can be controlled by light illumination. Comparatively, CoTCPP-TiO2 nanoshperes exhibit the highest peroxidase-like activity of three nanospheres (CoTCPP-TiO2, H2TCPP-TiO2 and TiO2) with similar morphology under the light illumination. Other than the existence of oxygen vacancy, the formation of heterostructure between TiO2 and a small amount of Co3O4 are ascribed to increase the catalytic activity of CoTCPP-TiO2 composites. Thus, a facile and convenient colorimetric sensing platform has been constructed and tuned by light illumination for determining H2O2 and amikacin in a good linear range of 20–100 and 50–100 μM with a limit of detection (LOD) of 3.04 μM and 1.88 μM, respectively. The CoTCPP-TiO2 based colorimetric sensing platform has been validated by measuring the amikacin residue in lake water. [Display omitted] •Metal porphyrin nanoaggregates not only are served as soft templates to control TiO2 morphology, but also are transformed heterogeneous structures to enhance catalytic activity during high-temperature treatment.•The light-operated CoTCPP-TiO2 nanozyme are used to construct a colorimetric method for first determination of amikacin.•CoTCPP-TiO2 nanoshperes exhibit the highest peroxidase-like activity of three nanospheres (CoTCPP-TiO2, H2TCPP-TiO2 and TiO2) under the light illumination.
ISSN:0039-9140
1873-3573
1873-3573
DOI:10.1016/j.talanta.2024.126889