Intra-individual comparison of epicardial adipose tissue characteristics on coronary CT angiography between photon-counting detector and energy-integrating detector CT systems

•EAT measurements between EID-CT and PCD-CT do not yield the same absolute results when accounting for slice thickness and kernel.•While absolute values differed between the two detector technologies, their tendencies showed good agreement.•New protocols and threshold ranges need to be developed for...

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Published in:European journal of radiology 2024-12, Vol.181, p.111728, Article 111728
Main Authors: Kravchenko, Dmitrij, Vecsey-Nagy, Milan, Tremamunno, Giuseppe, Schoepf, U. Joseph, O’Doherty, Jim, Luetkens, Julian A., Kuetting, Daniel, Isaak, Alexander, Hagar, Muhammad Taha, Emrich, Tilman, Varga-Szemes, Akos
Format: Article
Language:English
Subjects:
Energy-integrating detector CT
Epicardial adipose tissue
Photon-counting detector CT
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Summary:•EAT measurements between EID-CT and PCD-CT do not yield the same absolute results when accounting for slice thickness and kernel.•While absolute values differed between the two detector technologies, their tendencies showed good agreement.•New protocols and threshold ranges need to be developed for PCD-CT based EAT measurements to allow comparison to EID-CT. To explore the potential differences in epicardial adipose tissue (EAT) volume and attenuation measurements between photon-counting detector (PCD) and energy-integrating detector (EID)-CT systems. Fifty patients (mean age 69 ± 8 years, 41 male [82 %]) were prospectively enrolled for a research coronary CT angiography (CCTA) on a PCD-CT within 30 days after clinical EID-based CCTA. EID-CT acquisitions were reconstructed using a Bv40 kernel at 0.6 mm slice thickness. The PCD-CT acquisition was reconstructed at a down-sampled resolution (0.6 mm, Bv40; [PCD-DS]) and at ultra-high resolutions (PCD-UHR) with a 0.2 mm slice thickness and Bv40, Bv48, and Bv64 kernels. EAT segmentation was performed semi-automatically at about 1 cm intervals and interpolated to cover the whole epicardium within a threshold of −190 to −30 HU. A subgroup analysis was performed based on quartile groups created from EID-CT data and PCD-UHRBv48 data. Differences were measured using repeated-measures ANOVA and the Friedman test. Correlations were tested using Pearson’s and Spearman’s rho, and agreement using Bland-Altman plots. EAT volumes significantly differed between some reconstructions (e.g. EID-CT: 138 ml [IQR 100, 188]; PCD-DS: 147 ml [110, 206]; P
ISSN:0720-048X
1872-7727
1872-7727
DOI:10.1016/j.ejrad.2024.111728