Exploring the potential of epigenetic clocks in aging research

•Epigenetic clocks leverage artificial intelligence to predict biological age by analyzing specific age-related CpG sites.•An overview of classic epigenetic clocks is provided.•Epigenetic clocks are instrumental in identifying risk factors associated with aging and in evaluating the efficacy of anti...

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Bibliographic Details
Published in:Methods (San Diego, Calif.) Calif.), 2024-11, Vol.231, p.37-44
Main Authors: Hao, Yuduo, Han, Kaiyuan, Wang, Ting, Yu, Junwen, Ding, Hui, Dao, Fuying
Format: Article
Language:English
Subjects:
Aging
Biological age
Epigenetic age
Epigenetic age acceleration
Epigenetic clock
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Summary:•Epigenetic clocks leverage artificial intelligence to predict biological age by analyzing specific age-related CpG sites.•An overview of classic epigenetic clocks is provided.•Epigenetic clocks are instrumental in identifying risk factors associated with aging and in evaluating the efficacy of anti-aging interventions.•The potential of epigenetic clocks to predict the onset of aging-related diseases is explored.•The current limitations of epigenetic clocks are discussed, along with prospects for future development. The process of aging is a notable risk factor for numerous age-related illnesses. Hence, a reliable technique for evaluating biological age or the pace of aging is crucial for understanding the aging process and its influence on the progression of disease. Epigenetic alterations are recognized as a prominent biomarker of aging, and epigenetic clocks formulated on this basis have been shown to provide precise estimations of chronological age. Extensive research has validated the effectiveness of epigenetic clocks in determining aging rates, identifying risk factors for aging, evaluating the impact of anti-aging interventions, and predicting the emergence of age-related diseases. This review provides a detailed overview of the theoretical principles underlying the development of epigenetic clocks and their utility in aging research. Furthermore, it explores the existing obstacles and possibilities linked to epigenetic clocks and proposes potential avenues for future studies in this field
ISSN:1046-2023
1095-9130
1095-9130
DOI:10.1016/j.ymeth.2024.09.001