Racial/ethnic differences in the acute effects of reduced nicotine content cigarettes among adolescents who smoke

•Subjective evaluations of VLNC and NNC cigarettes varied by race/ethnicity.•VLNC and NNC effects on tobacco withdrawal did not differ by race/ethnicity.•VLNCs may reduce abuse liability and tobacco withdrawal for racial/ethnic youth. Reducing the nicotine content in cigarettes decreases their addic...

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Bibliographic Details
Published in:Addictive behaviors 2025-01, Vol.160, p.108147, Article 108147
Main Authors: Bello, Mariel S., Wang, Crystal X., Maglalang, Dale Dagar, Rosales, Robert, Tidey, Jennifer W., Denlinger-Apte, Rachel L., Sokolovsky, Alexander W., Colby, Suzanne M., Cassidy, Rachel N.
Format: Article
Language:English
Subjects:
Adolescents
Cigarettes
Nicotine content
Race/ethnicity
Subjective effects
Tobacco withdrawal
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Summary:•Subjective evaluations of VLNC and NNC cigarettes varied by race/ethnicity.•VLNC and NNC effects on tobacco withdrawal did not differ by race/ethnicity.•VLNCs may reduce abuse liability and tobacco withdrawal for racial/ethnic youth. Reducing the nicotine content in cigarettes decreases their addictiveness and abuse liability, including among adolescents. Whether these effects differ by race/ethnicity is unknown. This study is a secondary analysis of previously published data collected between 2014–2017. We examined racial/ethnic differences in the effects of smoking cigarettes with varying nicotine content levels on subjective effects and tobacco withdrawal among adolescents who smoke daily. Across two counterbalanced sessions, 50 adolescents recruited from Rhode Island (ages 15–19; 30 % Underrepresented Minorities [URM], 20 % Asians and Pacific Islanders [API]; 50 % Non-Hispanic Whites) self-administered a very low nicotine content (VLNC; 0.4 mg nicotine/g of tobacco) or normal nicotine content control (NNC; 15.8 mg/g) research cigarette following overnight abstinence. Subjective effects were reported post-administration and tobacco withdrawal outcomes were calculated from pre- to post-administration scores. Multilevel linear models tested main and interactive effects between cigarette nicotine content and race/ethnicity on all study outcomes. Participants reported lower positive subjective effects and reductions in smoking urges after smoking a VLNC cigarette relative to smoking an NNC cigarette (ps 
ISSN:0306-4603
1873-6327
1873-6327
DOI:10.1016/j.addbeh.2024.108147