Postacute Sequelae of COVID (PASC or Long COVID): An Evidenced-Based Approach

Abstract While the acute manifestations of infectious diseases are well known, in some individuals, symptoms can either persist or appear after the acute period. Postviral fatigue syndromes are recognized with other viral infections and are described after coronavirus disease 2019 (COVID-19). We hav...

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Bibliographic Details
Published in:Open forum infectious diseases 2024-08, Vol.11 (9), p.ofae462
Main Author: Griffin, Daniel O
Format: Article
Language:English
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Summary:Abstract While the acute manifestations of infectious diseases are well known, in some individuals, symptoms can either persist or appear after the acute period. Postviral fatigue syndromes are recognized with other viral infections and are described after coronavirus disease 2019 (COVID-19). We have a growing number of individuals with symptoms that persist for weeks, months, and years. Here, we share the evidence regarding the abnormalities associated with postacute sequelae of COVID-19 (PASC) and therapeutics. We describe physiological and biochemical abnormalities seen in individuals reporting PASC. We describe the several evidence-based interventions to offer patients. It is expected that this growing understanding of the mechanisms driving PASC and the benefits seen with certain therapeutics may not only lead to better outcomes for those with PASC but may also have the potential for understanding and treating other postinfectious sequelae. A growing number of individuals suffer from Long COVID. This article describes the objective physiological and biochemical abnormalities seen in these individuals and the different clinical phenotypes of Long COVID. This article shares the evidence-based interventions available for Long COVID.
ISSN:2328-8957
2328-8957
DOI:10.1093/ofid/ofae462